Revealing the novel autophagy-related genes for ligamentum flavum hypertrophy in patients and mice model

Revealing the novel autophagy-related genes for ligamentum flavum hypertrophy in patients and mice model

BackgroundFibrosis is a core pathological factor of ligamentum flavum hypertrophy (LFH) resulting in degenerative lumbar spinal stenosis. Autophagy plays a vital role in multi-organ fibrosis. However, autophagy has not been reported to be involved in the pathogenesis of LFH.MethodsThe LFH microarray...

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Bibliographic Details
Main Authors: Peng Li, Cheng-shuo Fei, Yan-lin Chen, Ze-sen Chen, Zhong-ming Lai, Rui-qian Tan, Yong-peng Yu, Xin Xiang, Jia-le Dong, Jun-xiong Zhang, Liang Wang, Zhong-min Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
ligamentum flavum hypertrophy
degenerative lumbar spinal stenosis
autophagy
fibrosis
bioinformatics analysis
bipedal standing mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.973799/full

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