Mitochondrial protein dysfunction in pathogenesis of neurological diseases
Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal in diverse cellular processes. The mitochondria...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.974480/full |
| _version_ | 1797998923592237056 |
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| author | Liang Wang Ziyun Yang Ziyun Yang Ziyun Yang Ziyun Yang Xiumei He Xiumei He Xiumei He Shiming Pu Shiming Pu Shiming Pu Cheng Yang Cheng Yang Cheng Yang Qiong Wu Qiong Wu Qiong Wu Zuping Zhou Zuping Zhou Xiaobo Cen Hongxia Zhao Hongxia Zhao Hongxia Zhao Hongxia Zhao |
| author_facet | Liang Wang Ziyun Yang Ziyun Yang Ziyun Yang Ziyun Yang Xiumei He Xiumei He Xiumei He Shiming Pu Shiming Pu Shiming Pu Cheng Yang Cheng Yang Cheng Yang Qiong Wu Qiong Wu Qiong Wu Zuping Zhou Zuping Zhou Xiaobo Cen Hongxia Zhao Hongxia Zhao Hongxia Zhao Hongxia Zhao |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | Mitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal in diverse cellular processes. The mitochondrial proteome encompasses about 1,500 proteins encoded by both the nuclear DNA and the maternally inherited mitochondrial DNA. Mutations in the nuclear or mitochondrial genome, or combinations of both, can result in mitochondrial protein deficiencies and mitochondrial malfunction. Therefore, mitochondrial quality control by proteins involved in various surveillance mechanisms is critical for neuronal integrity and viability. Abnormal proteins involved in mitochondrial bioenergetics, dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance have been linked to the pathogenesis of a number of neurological diseases. The goal of this review is to give an overview of these pathways and to summarize the interconnections between mitochondrial protein dysfunction and neurological diseases. |
| first_indexed | 2024-04-11T10:56:23Z |
| format | Article |
| id | doaj.art-5964c3fccd474802baa8d9b90c994817 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-11T10:56:23Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-5964c3fccd474802baa8d9b90c9948172022-12-22T04:28:45ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-09-011510.3389/fnmol.2022.974480974480Mitochondrial protein dysfunction in pathogenesis of neurological diseasesLiang Wang0Ziyun Yang1Ziyun Yang2Ziyun Yang3Ziyun Yang4Xiumei He5Xiumei He6Xiumei He7Shiming Pu8Shiming Pu9Shiming Pu10Cheng Yang11Cheng Yang12Cheng Yang13Qiong Wu14Qiong Wu15Qiong Wu16Zuping Zhou17Zuping Zhou18Xiaobo Cen19Hongxia Zhao20Hongxia Zhao21Hongxia Zhao22Hongxia Zhao23National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaNational Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaNational Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital of Sichuan University, Chengdu, ChinaSchool of Life Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Universities, Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, ChinaResearch Center for Biomedical Sciences, Guangxi Normal University, Guilin, ChinaFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, FinlandMitochondria are essential organelles for neuronal function and cell survival. Besides the well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid biogenesis, regulation of reactive oxygen species, and apoptosis are pivotal in diverse cellular processes. The mitochondrial proteome encompasses about 1,500 proteins encoded by both the nuclear DNA and the maternally inherited mitochondrial DNA. Mutations in the nuclear or mitochondrial genome, or combinations of both, can result in mitochondrial protein deficiencies and mitochondrial malfunction. Therefore, mitochondrial quality control by proteins involved in various surveillance mechanisms is critical for neuronal integrity and viability. Abnormal proteins involved in mitochondrial bioenergetics, dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance have been linked to the pathogenesis of a number of neurological diseases. The goal of this review is to give an overview of these pathways and to summarize the interconnections between mitochondrial protein dysfunction and neurological diseases.https://www.frontiersin.org/articles/10.3389/fnmol.2022.974480/fullmitochondrial proteinsneurological diseasespathogenesismitochondrial bioenergeticsmitochondrial dynamicsmitophagy |
| spellingShingle | Liang Wang Ziyun Yang Ziyun Yang Ziyun Yang Ziyun Yang Xiumei He Xiumei He Xiumei He Shiming Pu Shiming Pu Shiming Pu Cheng Yang Cheng Yang Cheng Yang Qiong Wu Qiong Wu Qiong Wu Zuping Zhou Zuping Zhou Xiaobo Cen Hongxia Zhao Hongxia Zhao Hongxia Zhao Hongxia Zhao Mitochondrial protein dysfunction in pathogenesis of neurological diseases Frontiers in Molecular Neuroscience mitochondrial proteins neurological diseases pathogenesis mitochondrial bioenergetics mitochondrial dynamics mitophagy |
| title | Mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| title_full | Mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| title_fullStr | Mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| title_full_unstemmed | Mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| title_short | Mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| title_sort | mitochondrial protein dysfunction in pathogenesis of neurological diseases |
| topic | mitochondrial proteins neurological diseases pathogenesis mitochondrial bioenergetics mitochondrial dynamics mitophagy |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.974480/full |
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