Suppression of medulloblastoma lesions by forced migration of preneoplastic precursor cells with intracerebellar administration of the chemokine Cxcl3

Suppression of medulloblastoma lesions by forced migration of preneoplastic precursor cells with intracerebellar administration of the chemokine Cxcl3

Medulloblastoma (MB), tumor of the cerebellum, remains a leading cause of cancer-related mortality in childhood.We previously showed, in a mouse model of spontaneous MB (Ptch1+/-/Tis21-/-), that a defect of the migration of cerebellar granule neuron precursor cells (GCPs) correlates with an increase...

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Bibliographic Details
Main Authors: Manuela Ceccarelli, Laura Micheli, Felice Tirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Pharmacology
Subjects:
Chemokines
Medulloblastoma
Migration
cancer therapy
differentiation and reprogramming
cerebellum development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00484/full

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