PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles
This article reports on polymer (PLLA, poly(L-lactic acid)) nanosheets incorporated with Fe-ion nanoparticles, aiming at using the latter nanoparticles as a source to release Fe ions. Such Fe ions should facilitate burn wound healing when such nanosheets are applied as a biomedical tissue on skin. L...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nanomanufacturing |
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| Online Access: | https://www.mdpi.com/2673-687X/3/4/25 |
| _version_ | 1827573916811395072 |
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| author | Aslan Mussin Ali A. AlJulaih Neli Mintcheva Delvin Aman Satoru Iwamori Stanislav O. Gurbatov Abhishek K. Bhardwaj Sergei A. Kulinich |
| author_facet | Aslan Mussin Ali A. AlJulaih Neli Mintcheva Delvin Aman Satoru Iwamori Stanislav O. Gurbatov Abhishek K. Bhardwaj Sergei A. Kulinich |
| author_sort | Aslan Mussin |
| collection | DOAJ |
| description | This article reports on polymer (PLLA, poly(L-lactic acid)) nanosheets incorporated with Fe-ion nanoparticles, aiming at using the latter nanoparticles as a source to release Fe ions. Such Fe ions should facilitate burn wound healing when such nanosheets are applied as a biomedical tissue on skin. Laser ablation in liquid phase was used to produce Fe-containing nanoparticles that, after incorporation into PLLA nanosheets, would release Fe ions upon immersion in water. Unlike most iron-oxide nanostructures, which are poorly soluble, such nanoparticles prepared in chloroform were found to have water solubility, as they were shown by XPS to be based on iron chloride and oxide phases. After incorporation into PLLA nanosheets, the ion-release test demonstrated that Fe ions could be released successfully into water at pH 7.4. Incorporation with two different metal ions (Fe and Zn) was also found to be efficient, as both types of ions were demonstrated to be released simultaneously and with comparable release rates. The results imply that such polymer nanosheets show promise for biomedical applications as potential patches for healing of burns. |
| first_indexed | 2024-03-08T20:28:56Z |
| format | Article |
| id | doaj.art-5968c2df94fe4a0f9cb8c0aa63f5a6ad |
| institution | Directory Open Access Journal |
| issn | 2673-687X |
| language | English |
| last_indexed | 2024-03-08T20:28:56Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomanufacturing |
| spelling | doaj.art-5968c2df94fe4a0f9cb8c0aa63f5a6ad2023-12-22T14:28:56ZengMDPI AGNanomanufacturing2673-687X2023-10-013440141510.3390/nanomanufacturing3040025PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing NanoparticlesAslan Mussin0Ali A. AlJulaih1Neli Mintcheva2Delvin Aman3Satoru Iwamori4Stanislav O. Gurbatov5Abhishek K. Bhardwaj6Sergei A. Kulinich7Department of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa 259-1292, JapanCatalysis Division, Petroleum Refining Department, Egyptian Petroleum Research Institute, Cairo 11727, EgyptDepartment of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa 259-1292, JapanInstitute of Automation and Control Processes, Far Eastern Branch, Russian Academy of Science, Vladivostok 690041, RussiaDepartment of Environmental Science, Amity University, Gwalior 474005, Madhya Pradesh, IndiaDepartment of Mechanical Engineering, Tokai University, Hiratsuka, Kanagawa 259-1292, JapanThis article reports on polymer (PLLA, poly(L-lactic acid)) nanosheets incorporated with Fe-ion nanoparticles, aiming at using the latter nanoparticles as a source to release Fe ions. Such Fe ions should facilitate burn wound healing when such nanosheets are applied as a biomedical tissue on skin. Laser ablation in liquid phase was used to produce Fe-containing nanoparticles that, after incorporation into PLLA nanosheets, would release Fe ions upon immersion in water. Unlike most iron-oxide nanostructures, which are poorly soluble, such nanoparticles prepared in chloroform were found to have water solubility, as they were shown by XPS to be based on iron chloride and oxide phases. After incorporation into PLLA nanosheets, the ion-release test demonstrated that Fe ions could be released successfully into water at pH 7.4. Incorporation with two different metal ions (Fe and Zn) was also found to be efficient, as both types of ions were demonstrated to be released simultaneously and with comparable release rates. The results imply that such polymer nanosheets show promise for biomedical applications as potential patches for healing of burns.https://www.mdpi.com/2673-687X/3/4/25PLLA nanosheetslaser ablation in liquidFe-containing nanoparticlesmetal-ion releaseburn wound healing |
| spellingShingle | Aslan Mussin Ali A. AlJulaih Neli Mintcheva Delvin Aman Satoru Iwamori Stanislav O. Gurbatov Abhishek K. Bhardwaj Sergei A. Kulinich PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles Nanomanufacturing PLLA nanosheets laser ablation in liquid Fe-containing nanoparticles metal-ion release burn wound healing |
| title | PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles |
| title_full | PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles |
| title_fullStr | PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles |
| title_full_unstemmed | PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles |
| title_short | PLLA Nanosheets for Wound Healing: Embedding with Iron-Ion-Containing Nanoparticles |
| title_sort | plla nanosheets for wound healing embedding with iron ion containing nanoparticles |
| topic | PLLA nanosheets laser ablation in liquid Fe-containing nanoparticles metal-ion release burn wound healing |
| url | https://www.mdpi.com/2673-687X/3/4/25 |
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