Review on Current Status of Echinocandins Use
Fungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower si...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/5/227 |
| _version_ | 1797569042222940160 |
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| author | Martyna Mroczyńska Anna Brillowska-Dąbrowska |
| author_facet | Martyna Mroczyńska Anna Brillowska-Dąbrowska |
| author_sort | Martyna Mroczyńska |
| collection | DOAJ |
| description | Fungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the biosynthesis of β-(1,3)-D-glucan. These compounds have fungicidal and fungistatic activity depending on different genera of fungi, against which they are used. Echinocandin resistance is rare—the major cause of resistance is mutations in the gene encoding the β-(1,3)-D-glucan synthase enzyme. In this review of the literature we have summarized the characteristics of echinocandins, the mechanism of their antifungal activity with pharmacokinetics and pharmacodynamics, and the resistance issue. |
| first_indexed | 2024-03-10T20:05:20Z |
| format | Article |
| id | doaj.art-596975cefa4b43a8a3c583343ffc13f0 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T20:05:20Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-596975cefa4b43a8a3c583343ffc13f02023-11-19T23:18:36ZengMDPI AGAntibiotics2079-63822020-05-019522710.3390/antibiotics9050227Review on Current Status of Echinocandins UseMartyna Mroczyńska0Anna Brillowska-Dąbrowska1Department of Molecular Biotechnology and Microbiology, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, PolandDepartment of Molecular Biotechnology and Microbiology, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, PolandFungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the biosynthesis of β-(1,3)-D-glucan. These compounds have fungicidal and fungistatic activity depending on different genera of fungi, against which they are used. Echinocandin resistance is rare—the major cause of resistance is mutations in the gene encoding the β-(1,3)-D-glucan synthase enzyme. In this review of the literature we have summarized the characteristics of echinocandins, the mechanism of their antifungal activity with pharmacokinetics and pharmacodynamics, and the resistance issue.https://www.mdpi.com/2079-6382/9/5/227antimycoticfungal infectionsechinocandin resistance |
| spellingShingle | Martyna Mroczyńska Anna Brillowska-Dąbrowska Review on Current Status of Echinocandins Use Antibiotics antimycotic fungal infections echinocandin resistance |
| title | Review on Current Status of Echinocandins Use |
| title_full | Review on Current Status of Echinocandins Use |
| title_fullStr | Review on Current Status of Echinocandins Use |
| title_full_unstemmed | Review on Current Status of Echinocandins Use |
| title_short | Review on Current Status of Echinocandins Use |
| title_sort | review on current status of echinocandins use |
| topic | antimycotic fungal infections echinocandin resistance |
| url | https://www.mdpi.com/2079-6382/9/5/227 |
| work_keys_str_mv | AT martynamroczynska reviewoncurrentstatusofechinocandinsuse AT annabrillowskadabrowska reviewoncurrentstatusofechinocandinsuse |