Olfactory Ensheathing Cells Grafted Into the Retina of RCS Rats Suppress Inflammation by Down-Regulating the JAK/STAT Pathway

Olfactory Ensheathing Cells Grafted Into the Retina of RCS Rats Suppress Inflammation by Down-Regulating the JAK/STAT Pathway

The inflammatory microenvironment in the retina plays a vital role in the pathogenesis and progression of retinitis pigmentosa (RP). Microglial inflammatory cytokines production leads to gliosis and apoptosis of retinal neurons, and ultimately, visual loss. Cell-based therapies using grafted olfacto...

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Bibliographic Details
Main Authors: Jing Xie, Yijian Li, Jiaman Dai, Yan He, Dayu Sun, Chao Dai, Haiwei Xu, Zheng Qin Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
retinitis pigmentosa
microglia
infiltrated macrophage neuroinflammation
JAK/STAT pathway
olfactory ensheathing cell
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00341/full

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