Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers
Background/aim: The safety of amateur and professional boxing is a contentious issue. We hypothesised that advanced magnetic resonance imaging and neuropsychological testing could provide evidence of acute and early brain injury in amateur boxers. Methods: We recruited 30 participants from a univers...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-01-01
|
| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217301031 |
| _version_ | 1818847357266034688 |
|---|---|
| author | M.G. Hart C.R. Housden J. Suckling R. Tait A. Young U. Müller V.F.J. Newcombe I. Jalloh B. Pearson J. Cross R.A. Trivedi J.D. Pickard B.J. Sahakian P.J. Hutchinson |
| author_facet | M.G. Hart C.R. Housden J. Suckling R. Tait A. Young U. Müller V.F.J. Newcombe I. Jalloh B. Pearson J. Cross R.A. Trivedi J.D. Pickard B.J. Sahakian P.J. Hutchinson |
| author_sort | M.G. Hart |
| collection | DOAJ |
| description | Background/aim: The safety of amateur and professional boxing is a contentious issue. We hypothesised that advanced magnetic resonance imaging and neuropsychological testing could provide evidence of acute and early brain injury in amateur boxers. Methods: We recruited 30 participants from a university amateur boxing club in a prospective cohort study. Magnetic resonance imaging (MRI) and neuropsychological testing was performed at three time points: prior to starting training; within 48h following a first major competition to detect acute brain injury; and one year follow-up. A single MRI acquisition was made from control participants. Imaging analysis included cortical thickness measurements with Advanced Normalization Tools (ANTS) and FreeSurfer, voxel based morphometry (VBM), and Tract Based Spatial Statistics (TBSS). A computerized battery of neuropsychological tests was performed assessing attention, learning, memory and impulsivity. Results: During the study period, one boxer developed seizures controlled with medication while another developed a chronic subdural hematoma requiring neurosurgical drainage. A total of 10 boxers contributed data at to the longitudinal assessment protocol. Reasons for withdrawal were: logistics (10), stopping boxing (7), withdrawal of consent (2), and development of a chronic subdural hematoma (1). No significant changes were detected using VBM, TBSS, cortical thickness measured with FreeSurfer or ANTS, either cross-sectionally at baseline, or longitudinally. Neuropsychological assessment of boxers found attention/concentration improved over time while planning and problem solving ability latency decreased after a bout but recovered after one year. Conclusion: While this neuroimaging and neuropsychological assessment protocol could not detect any evidence of brain injury, one boxer developed seizures and another developed a chronic sub-dural haematoma. Keywords: Boxing, Neuroimaging, Brain structure, CANTAB |
| first_indexed | 2024-12-19T06:00:10Z |
| format | Article |
| id | doaj.art-596d27fd47b54a2dbd0601038e760c6d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-19T06:00:10Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-596d27fd47b54a2dbd0601038e760c6d2022-12-21T20:33:20ZengElsevierNeuroImage: Clinical2213-15822017-01-0115194199Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxersM.G. Hart0C.R. Housden1J. Suckling2R. Tait3A. Young4U. Müller5V.F.J. Newcombe6I. Jalloh7B. Pearson8J. Cross9R.A. Trivedi10J.D. Pickard11B.J. Sahakian12P.J. Hutchinson13Academic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Corresponding author at: Department of Neurosurgery, Box 166, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.Department of Psychiatry, University of Cambridge and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, United KingdomDepartment of Psychiatry, University of Cambridge and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, United KingdomDepartment of Psychiatry, University of Cambridge and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomDepartment of Psychiatry, University of Cambridge and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, United Kingdom; Adult ADHD Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge Road, Fulbourn, Cambridge CB21 5HH, United KingdomWolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; University Division of Anaesthesia, University of Cambridge, Cambridge CB2 0QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomDepartment of Radiology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomDepartment of Psychiatry, University of Cambridge and the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Cambridge CB2 2QQ, United KingdomAcademic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United KingdomBackground/aim: The safety of amateur and professional boxing is a contentious issue. We hypothesised that advanced magnetic resonance imaging and neuropsychological testing could provide evidence of acute and early brain injury in amateur boxers. Methods: We recruited 30 participants from a university amateur boxing club in a prospective cohort study. Magnetic resonance imaging (MRI) and neuropsychological testing was performed at three time points: prior to starting training; within 48h following a first major competition to detect acute brain injury; and one year follow-up. A single MRI acquisition was made from control participants. Imaging analysis included cortical thickness measurements with Advanced Normalization Tools (ANTS) and FreeSurfer, voxel based morphometry (VBM), and Tract Based Spatial Statistics (TBSS). A computerized battery of neuropsychological tests was performed assessing attention, learning, memory and impulsivity. Results: During the study period, one boxer developed seizures controlled with medication while another developed a chronic subdural hematoma requiring neurosurgical drainage. A total of 10 boxers contributed data at to the longitudinal assessment protocol. Reasons for withdrawal were: logistics (10), stopping boxing (7), withdrawal of consent (2), and development of a chronic subdural hematoma (1). No significant changes were detected using VBM, TBSS, cortical thickness measured with FreeSurfer or ANTS, either cross-sectionally at baseline, or longitudinally. Neuropsychological assessment of boxers found attention/concentration improved over time while planning and problem solving ability latency decreased after a bout but recovered after one year. Conclusion: While this neuroimaging and neuropsychological assessment protocol could not detect any evidence of brain injury, one boxer developed seizures and another developed a chronic sub-dural haematoma. Keywords: Boxing, Neuroimaging, Brain structure, CANTABhttp://www.sciencedirect.com/science/article/pii/S2213158217301031 |
| spellingShingle | M.G. Hart C.R. Housden J. Suckling R. Tait A. Young U. Müller V.F.J. Newcombe I. Jalloh B. Pearson J. Cross R.A. Trivedi J.D. Pickard B.J. Sahakian P.J. Hutchinson Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers NeuroImage: Clinical |
| title | Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| title_full | Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| title_fullStr | Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| title_full_unstemmed | Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| title_short | Advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| title_sort | advanced magnetic resonance imaging and neuropsychological assessment for detecting brain injury in a prospective cohort of university amateur boxers |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217301031 |
| work_keys_str_mv | AT mghart advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT crhousden advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT jsuckling advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT rtait advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT ayoung advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT umuller advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT vfjnewcombe advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT ijalloh advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT bpearson advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT jcross advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT ratrivedi advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT jdpickard advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT bjsahakian advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers AT pjhutchinson advancedmagneticresonanceimagingandneuropsychologicalassessmentfordetectingbraininjuryinaprospectivecohortofuniversityamateurboxers |