Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study
Abstract Purpose To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. Methods IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospec...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-04-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-020-01516-4 |
| _version_ | 1811270669764132864 |
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| author | Lucas C. Mendez Ananth Ravi Kevin Martell Hamid Raziee Yasir Alayed Matt Wronski Moti Paudel Elizabeth Barnes Amandeep Taggar C. S. Wong Eric Leung |
| author_facet | Lucas C. Mendez Ananth Ravi Kevin Martell Hamid Raziee Yasir Alayed Matt Wronski Moti Paudel Elizabeth Barnes Amandeep Taggar C. S. Wong Eric Leung |
| author_sort | Lucas C. Mendez |
| collection | DOAJ |
| description | Abstract Purpose To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. Methods IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospectively enrolled in this study. Radiation oncologists contoured CTVHR and OARs in pre-BT MR images (MRI) and intra-operative TRUS images. These contours were subsequently compared in regard to volume and dimension. Contour inter-rater agreement analysis was also investigated using kappa index (KI). Stata 15.0 was used for statistical analysis and a p-value < 0.05 was considered statistically significant. Results TRUS CTVHR volumes were statistically smaller than the respective MRI contoured volumes. TRUS CTVHR thickness was found to be consistently smaller than MRI contours in all patients. No statistical difference was seen in width and height between the two different imaging modalities. MRI contours had a median KI of 0.66 (range: 0.56–0.77) while TRUS-based contours had a median KI of 0.64 (range: 0.47–0.77). Bladder and rectum had very satisfactory KI in both imaging modalities. Vaginal contours had moderate agreement in MR (0.52) and in TRUS images (0.58). Conclusion TRUS images allow good visualization of CTVHR and OARs in IB cervical cancer patients. Inter-rater contour variability was comparable between TRUS and MR images. TRUS is a promising modality on its own for image-guided BT. |
| first_indexed | 2024-04-12T22:06:13Z |
| format | Article |
| id | doaj.art-596e0b9e12a04cbea17929c54583d403 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-12T22:06:13Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-596e0b9e12a04cbea17929c54583d4032022-12-22T03:14:56ZengBMCRadiation Oncology1748-717X2020-04-011511810.1186/s13014-020-01516-4Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept studyLucas C. Mendez0Ananth Ravi1Kevin Martell2Hamid Raziee3Yasir Alayed4Matt Wronski5Moti Paudel6Elizabeth Barnes7Amandeep Taggar8C. S. Wong9Eric Leung10Department of Radiation Oncology, University of TorontoSunnybrook Health Sciences CentreDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoSunnybrook Health Sciences CentreSunnybrook Health Sciences CentreDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoDepartment of Radiation Oncology, University of TorontoAbstract Purpose To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients. Methods IB cervical cancer patients treated with (chemo)radiotherapy plus MR-guided brachytherapy (BT) were prospectively enrolled in this study. Radiation oncologists contoured CTVHR and OARs in pre-BT MR images (MRI) and intra-operative TRUS images. These contours were subsequently compared in regard to volume and dimension. Contour inter-rater agreement analysis was also investigated using kappa index (KI). Stata 15.0 was used for statistical analysis and a p-value < 0.05 was considered statistically significant. Results TRUS CTVHR volumes were statistically smaller than the respective MRI contoured volumes. TRUS CTVHR thickness was found to be consistently smaller than MRI contours in all patients. No statistical difference was seen in width and height between the two different imaging modalities. MRI contours had a median KI of 0.66 (range: 0.56–0.77) while TRUS-based contours had a median KI of 0.64 (range: 0.47–0.77). Bladder and rectum had very satisfactory KI in both imaging modalities. Vaginal contours had moderate agreement in MR (0.52) and in TRUS images (0.58). Conclusion TRUS images allow good visualization of CTVHR and OARs in IB cervical cancer patients. Inter-rater contour variability was comparable between TRUS and MR images. TRUS is a promising modality on its own for image-guided BT.http://link.springer.com/article/10.1186/s13014-020-01516-4Cervical cancerBrachytherapyTransrectal ultrasound |
| spellingShingle | Lucas C. Mendez Ananth Ravi Kevin Martell Hamid Raziee Yasir Alayed Matt Wronski Moti Paudel Elizabeth Barnes Amandeep Taggar C. S. Wong Eric Leung Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study Radiation Oncology Cervical cancer Brachytherapy Transrectal ultrasound |
| title | Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
| title_full | Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
| title_fullStr | Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
| title_full_unstemmed | Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
| title_short | Comparison of CTVHR and organs at risk contours between TRUS and MR images in IB cervical cancers: a proof of concept study |
| title_sort | comparison of ctvhr and organs at risk contours between trus and mr images in ib cervical cancers a proof of concept study |
| topic | Cervical cancer Brachytherapy Transrectal ultrasound |
| url | http://link.springer.com/article/10.1186/s13014-020-01516-4 |
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