The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease
IntroductionSubjective cognitive decline (SCD) with a positive amyloid burden has been recognized as the earliest clinical symptom of the preclinical phase of Alzheimers disease (AD), providing invaluable opportunities to improve our understanding of the natural history of AD and determine strategie...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223697/full |
| _version_ | 1797645771816828928 |
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| author | Yu Sun Yanan Qiao Jing Guo Wenjie Hou Yaojing Chen Dantao Peng |
| author_facet | Yu Sun Yanan Qiao Jing Guo Wenjie Hou Yaojing Chen Dantao Peng |
| author_sort | Yu Sun |
| collection | DOAJ |
| description | IntroductionSubjective cognitive decline (SCD) with a positive amyloid burden has been recognized as the earliest clinical symptom of the preclinical phase of Alzheimers disease (AD), providing invaluable opportunities to improve our understanding of the natural history of AD and determine strategies for early therapeutic interventions.MethodsThe microstructure of white matter in patients showing SCD in the preclinical phase of AD (SCD of pre-AD) was evaluated using diffusion images, and voxel-wise fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities were assessed and compared among participant groups. Significant clusters in the tracts were extracted to determine their associations with alterations in the cognitive domains.ResultsWe found that individuals with SCD of pre-AD may have subclinical episodic memory impairment associated with the global amyloid burden. Meanwhile, we found significantly reduced FA and λ1 in the right cingulum (cingulate and hippocampus) in AD dementia, while significantly increased FA and decreased MD as well as λ23 in the SCD of pre-AD group in comparison with the HC group.DiscussionIn conclusion, increased white matter microstructural integrity in the right cingulum (cingulate and hippocampus) may indicate compensation for short-term episodic memory in individuals with SCD of pre-AD in comparison with individuals with AD and healthy elderly individuals. |
| first_indexed | 2024-03-11T14:51:48Z |
| format | Article |
| id | doaj.art-596e3538c01842fa8c47f9615b53aaa8 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T14:51:48Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-596e3538c01842fa8c47f9615b53aaa82023-10-30T09:06:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-10-011510.3389/fnagi.2023.12236971223697The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s diseaseYu Sun0Yanan Qiao1Jing Guo2Wenjie Hou3Yaojing Chen4Dantao Peng5Department of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaIntroductionSubjective cognitive decline (SCD) with a positive amyloid burden has been recognized as the earliest clinical symptom of the preclinical phase of Alzheimers disease (AD), providing invaluable opportunities to improve our understanding of the natural history of AD and determine strategies for early therapeutic interventions.MethodsThe microstructure of white matter in patients showing SCD in the preclinical phase of AD (SCD of pre-AD) was evaluated using diffusion images, and voxel-wise fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities were assessed and compared among participant groups. Significant clusters in the tracts were extracted to determine their associations with alterations in the cognitive domains.ResultsWe found that individuals with SCD of pre-AD may have subclinical episodic memory impairment associated with the global amyloid burden. Meanwhile, we found significantly reduced FA and λ1 in the right cingulum (cingulate and hippocampus) in AD dementia, while significantly increased FA and decreased MD as well as λ23 in the SCD of pre-AD group in comparison with the HC group.DiscussionIn conclusion, increased white matter microstructural integrity in the right cingulum (cingulate and hippocampus) may indicate compensation for short-term episodic memory in individuals with SCD of pre-AD in comparison with individuals with AD and healthy elderly individuals.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223697/fullAlzheimer’s diseasesubjective cognitive declinediffusion tensor imagingcingulumcompensatory mechanism |
| spellingShingle | Yu Sun Yanan Qiao Jing Guo Wenjie Hou Yaojing Chen Dantao Peng The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease Frontiers in Aging Neuroscience Alzheimer’s disease subjective cognitive decline diffusion tensor imaging cingulum compensatory mechanism |
| title | The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease |
| title_full | The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease |
| title_fullStr | The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease |
| title_full_unstemmed | The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease |
| title_short | The preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of Alzheimer’s disease |
| title_sort | preservation of right cingulum fibers in subjective cognitive decline of preclinical phase of alzheimer s disease |
| topic | Alzheimer’s disease subjective cognitive decline diffusion tensor imaging cingulum compensatory mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223697/full |
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