Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds
In this article, poly(lactic-co-glycolic acid) (PLGA) microspheres containing the drug OIC-A006 were prepared by ice bath extraction and poly(lactic-co-glycolic acid)/ β-tricalcium phosphate (PLGA/β-TCP) scaffolds were prepared by freeze-drying. Three kinds of scaffold were prepared by adding no dru...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-09-01
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| Series: | Science and Engineering of Composite Materials |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/secm-2015-0372 |
| _version_ | 1829499040816955392 |
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| author | Lin Liulan Dong Yangyang Zhou Qi |
| author_facet | Lin Liulan Dong Yangyang Zhou Qi |
| author_sort | Lin Liulan |
| collection | DOAJ |
| description | In this article, poly(lactic-co-glycolic acid) (PLGA) microspheres containing the drug OIC-A006 were prepared by ice bath extraction and poly(lactic-co-glycolic acid)/ β-tricalcium phosphate (PLGA/β-TCP) scaffolds were prepared by freeze-drying. Three kinds of scaffold were prepared by adding no drug, direct loading the drug, and loading with drug microspheres. The mechanical strength, degradation, and microstructure of the scaffolds were analyzed. The drug delivery properties of the scaffolds were determined using high-performance liquid chromatography (HPLC). It was found that PLGA/β-TCP scaffolds with PLGA microspheres that contained the drug OIC-A006 exhibited a biphasic drug release pattern. Sustained release of the drug OIC-A006 was beneficial to cell adhesion and proliferation. Experiments on rats showed that composite PLGA/β-TCP scaffolds with PLGA microspheres containing the drug OIC-A006 produced good bone formation and bone induction. |
| first_indexed | 2024-12-16T08:25:41Z |
| format | Article |
| id | doaj.art-596e7f7da7f5456bafc3fd4530c16a25 |
| institution | Directory Open Access Journal |
| issn | 0792-1233 2191-0359 |
| language | English |
| last_indexed | 2024-12-16T08:25:41Z |
| publishDate | 2017-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Science and Engineering of Composite Materials |
| spelling | doaj.art-596e7f7da7f5456bafc3fd4530c16a252022-12-21T22:38:00ZengDe GruyterScience and Engineering of Composite Materials0792-12332191-03592017-09-0124572173010.1515/secm-2015-0372Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffoldsLin Liulan0Dong Yangyang1Zhou Qi2Rapid Manufacture Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, 99 Shangda Road, BaoShan District, Shanghai 200444, ChinaRapid Manufacture Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, 99 Shangda Road, BaoShan District, Shanghai 200444, ChinaShanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, ChinaIn this article, poly(lactic-co-glycolic acid) (PLGA) microspheres containing the drug OIC-A006 were prepared by ice bath extraction and poly(lactic-co-glycolic acid)/ β-tricalcium phosphate (PLGA/β-TCP) scaffolds were prepared by freeze-drying. Three kinds of scaffold were prepared by adding no drug, direct loading the drug, and loading with drug microspheres. The mechanical strength, degradation, and microstructure of the scaffolds were analyzed. The drug delivery properties of the scaffolds were determined using high-performance liquid chromatography (HPLC). It was found that PLGA/β-TCP scaffolds with PLGA microspheres that contained the drug OIC-A006 exhibited a biphasic drug release pattern. Sustained release of the drug OIC-A006 was beneficial to cell adhesion and proliferation. Experiments on rats showed that composite PLGA/β-TCP scaffolds with PLGA microspheres containing the drug OIC-A006 produced good bone formation and bone induction.https://doi.org/10.1515/secm-2015-0372bone repair materialscontrolled drug releasedrug-loaded microspheresfreeze-drying technologyoic-a006 |
| spellingShingle | Lin Liulan Dong Yangyang Zhou Qi Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds Science and Engineering of Composite Materials bone repair materials controlled drug release drug-loaded microspheres freeze-drying technology oic-a006 |
| title | Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds |
| title_full | Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds |
| title_fullStr | Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds |
| title_full_unstemmed | Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds |
| title_short | Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds |
| title_sort | sustained release of oic a006 from plga microspheres to induce osteogenesis of composite plga β tcp scaffolds |
| topic | bone repair materials controlled drug release drug-loaded microspheres freeze-drying technology oic-a006 |
| url | https://doi.org/10.1515/secm-2015-0372 |
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