Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells
The understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors show that macrophages within the primary tumor in...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28076-3 |
| _version_ | 1818499392291733504 |
|---|---|
| author | Lucia Borriello Anouchka Coste Brian Traub Ved P. Sharma George S. Karagiannis Yu Lin Yarong Wang Xianjun Ye Camille L. Duran Xiaoming Chen Madeline Friedman Maria Soledad Sosa Dan Sun Erica Dalla Deepak K. Singh Maja H. Oktay Julio A. Aguirre-Ghiso John S. Condeelis David Entenberg |
| author_facet | Lucia Borriello Anouchka Coste Brian Traub Ved P. Sharma George S. Karagiannis Yu Lin Yarong Wang Xianjun Ye Camille L. Duran Xiaoming Chen Madeline Friedman Maria Soledad Sosa Dan Sun Erica Dalla Deepak K. Singh Maja H. Oktay Julio A. Aguirre-Ghiso John S. Condeelis David Entenberg |
| author_sort | Lucia Borriello |
| collection | DOAJ |
| description | The understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors show that macrophages within the primary tumor induce a pro-dissemination and pro-dormancy phenotype in tumor cells, favouring their extravasation in the lung. |
| first_indexed | 2024-12-10T20:28:47Z |
| format | Article |
| id | doaj.art-5970a40bc7bc451f81378de22f3362d1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:28:47Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5970a40bc7bc451f81378de22f3362d12022-12-22T01:34:45ZengNature PortfolioNature Communications2041-17232022-02-0113111910.1038/s41467-022-28076-3Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cellsLucia Borriello0Anouchka Coste1Brian Traub2Ved P. Sharma3George S. Karagiannis4Yu Lin5Yarong Wang6Xianjun Ye7Camille L. Duran8Xiaoming Chen9Madeline Friedman10Maria Soledad Sosa11Dan Sun12Erica Dalla13Deepak K. Singh14Maja H. Oktay15Julio A. Aguirre-Ghiso16John S. Condeelis17David Entenberg18Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterGruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiCancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical CenterDivision of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiCancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterGruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical CenterThe understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors show that macrophages within the primary tumor induce a pro-dissemination and pro-dormancy phenotype in tumor cells, favouring their extravasation in the lung.https://doi.org/10.1038/s41467-022-28076-3 |
| spellingShingle | Lucia Borriello Anouchka Coste Brian Traub Ved P. Sharma George S. Karagiannis Yu Lin Yarong Wang Xianjun Ye Camille L. Duran Xiaoming Chen Madeline Friedman Maria Soledad Sosa Dan Sun Erica Dalla Deepak K. Singh Maja H. Oktay Julio A. Aguirre-Ghiso John S. Condeelis David Entenberg Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells Nature Communications |
| title | Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| title_full | Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| title_fullStr | Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| title_full_unstemmed | Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| title_short | Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| title_sort | primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells |
| url | https://doi.org/10.1038/s41467-022-28076-3 |
| work_keys_str_mv | AT luciaborriello primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT anouchkacoste primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT briantraub primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT vedpsharma primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT georgeskaragiannis primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT yulin primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT yarongwang primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT xianjunye primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT camillelduran primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT xiaomingchen primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT madelinefriedman primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT mariasoledadsosa primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT dansun primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT ericadalla primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT deepakksingh primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT majahoktay primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT julioaaguirreghiso primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT johnscondeelis primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells AT davidentenberg primarytumorassociatedmacrophagesactivateprogramsofinvasionanddormancyindisseminatingtumorcells |