The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies
Objective: The actual efficacy of magnesium and its alloy in anterior cruciate ligament reconstruction (ACLR) was systematically evaluated to reduce the risk of translation from animal experiments to the clinic.Methods: Databases of PubMed, Ovid-Embase, Web of Science, CNKI, Wanfang, VIP, and CBM we...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.789498/full |
| _version_ | 1818834272716324864 |
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| author | Zhizhong Shang Dongliang Li Jinlei Chen Mingchuan Wang Baolin Zhang Xin Wang Xin Wang Bin Ma |
| author_facet | Zhizhong Shang Dongliang Li Jinlei Chen Mingchuan Wang Baolin Zhang Xin Wang Xin Wang Bin Ma |
| author_sort | Zhizhong Shang |
| collection | DOAJ |
| description | Objective: The actual efficacy of magnesium and its alloy in anterior cruciate ligament reconstruction (ACLR) was systematically evaluated to reduce the risk of translation from animal experiments to the clinic.Methods: Databases of PubMed, Ovid-Embase, Web of Science, CNKI, Wanfang, VIP, and CBM were searched for literature in July 2021. Screening of search results, data extraction, and literature quality evaluation were undertaken independently by two reviewers.Results and discussion: Seven articles were selected for the meta-analysis. The results showed that the mechanical properties of the femoral-tendon graft–tibia complex fixed with magnesium and its alloys were comparable to those fixed with titanium and its alloys, and magnesium and its alloys were superior to titanium and its alloys in promoting new bone formation. In addition, the unique biodegradability made magnesium and its alloys an orthopedic implant with significant therapeutic potential. However, whether the degradation rate of magnesium and its alloy can match the rate of bone-tendon integration, and whether the bioconjugation of bone-tendon after degradation can meet the exercise load still needs to be explored in further detail. Simultaneously, it is necessary for future research to improve and standardize experimental design, result measurement, etc., so as to minimize the risk of transforming animal experimental results into clinical practice. |
| first_indexed | 2024-12-19T02:32:11Z |
| format | Article |
| id | doaj.art-597407710cf84ec496c7bc74182c6a9a |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-19T02:32:11Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-597407710cf84ec496c7bc74182c6a9a2022-12-21T20:39:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-11-01910.3389/fbioe.2021.789498789498The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal StudiesZhizhong Shang0Dongliang Li1Jinlei Chen2Mingchuan Wang3Baolin Zhang4Xin Wang5Xin Wang6Bin Ma7The First Clinical Medical School of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou, ChinaDepartment of Spine, Changzheng Hospital, Naval Medical University, Shanghai, ChinaEvidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, ChinaObjective: The actual efficacy of magnesium and its alloy in anterior cruciate ligament reconstruction (ACLR) was systematically evaluated to reduce the risk of translation from animal experiments to the clinic.Methods: Databases of PubMed, Ovid-Embase, Web of Science, CNKI, Wanfang, VIP, and CBM were searched for literature in July 2021. Screening of search results, data extraction, and literature quality evaluation were undertaken independently by two reviewers.Results and discussion: Seven articles were selected for the meta-analysis. The results showed that the mechanical properties of the femoral-tendon graft–tibia complex fixed with magnesium and its alloys were comparable to those fixed with titanium and its alloys, and magnesium and its alloys were superior to titanium and its alloys in promoting new bone formation. In addition, the unique biodegradability made magnesium and its alloys an orthopedic implant with significant therapeutic potential. However, whether the degradation rate of magnesium and its alloy can match the rate of bone-tendon integration, and whether the bioconjugation of bone-tendon after degradation can meet the exercise load still needs to be explored in further detail. Simultaneously, it is necessary for future research to improve and standardize experimental design, result measurement, etc., so as to minimize the risk of transforming animal experimental results into clinical practice.https://www.frontiersin.org/articles/10.3389/fbioe.2021.789498/fullmagnesium and its alloystitanium and its alloysanterior cruciate ligament reconstructionanimal studysystematic review |
| spellingShingle | Zhizhong Shang Dongliang Li Jinlei Chen Mingchuan Wang Baolin Zhang Xin Wang Xin Wang Bin Ma The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies Frontiers in Bioengineering and Biotechnology magnesium and its alloys titanium and its alloys anterior cruciate ligament reconstruction animal study systematic review |
| title | The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies |
| title_full | The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies |
| title_fullStr | The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies |
| title_full_unstemmed | The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies |
| title_short | The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies |
| title_sort | role of biodegradable magnesium and its alloys in anterior cruciate ligament reconstruction a systematic review and meta analysis based on animal studies |
| topic | magnesium and its alloys titanium and its alloys anterior cruciate ligament reconstruction animal study systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.789498/full |
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