A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study
<p>Abstract</p> <p>Background</p> <p>Interest in translational studies aimed at investigating biologic markers in predicting response to primary chemotherapy (PCT) in breast cancer has progressively increased. We conducted a pilot study to evaluate feasibility of evalua...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-03-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/7/1/35 |
| _version_ | 1818964325313806336 |
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| author | Vijaykumar DK Pavithran K Hiran KR Sharma Shekhar |
| author_facet | Vijaykumar DK Pavithran K Hiran KR Sharma Shekhar |
| author_sort | Vijaykumar DK |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Interest in translational studies aimed at investigating biologic markers in predicting response to primary chemotherapy (PCT) in breast cancer has progressively increased. We conducted a pilot study to evaluate feasibility of evaluating biomarkers of response to PCT at one & 21 days after first cycle.</p> <p>Methods</p> <p>Adult, non-pregnant, non-lactating women with histologically confirmed infiltrating duct carcinoma underwent serial core biopsies after first cycle of PCT and these were scored for <it>Ki</it>-67, <it>Bcl</it>-2 and <it>Caspase</it>-3 using immunohistochemistry.</p> <p>Results</p> <p>We recruited 30 patients with a mean age of 51 years. We were successful 95.6% times in performing a core biopsy and of these 84.6% had adequate tissue in the cores harvested. After a mean of 4 cycles of PCT, 26 patients underwent surgery and good response was noted in 9 patients (30%) using Miller-Payne criteria. There was a trend noted in all markers, which appeared different in those with good response and poor response. Good responders had significantly higher <it>Ki-67 </it>and significantly lower <it>Bcl</it>-2 at baseline and a significant decrease in <it>Ki-67 </it>and <it>Caspase-3 </it>at 21 days after the first chemotherapy.</p> <p>Conclusion</p> <p>We report a detectable change in biomarkers as early as 24–48 hours after the first chemotherapy along with a definite trend in change that can possibly be used to predict response to chemotherapy in an individual patient. The statistical significance and clinical utility of such changes needs to be evaluated and confirmed in larger trials.</p> |
| first_indexed | 2024-12-20T12:59:19Z |
| format | Article |
| id | doaj.art-59740cc7f5bc4ece9055ac334a9b126c |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-20T12:59:19Z |
| publishDate | 2009-03-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-59740cc7f5bc4ece9055ac334a9b126c2022-12-21T19:39:58ZengBMCWorld Journal of Surgical Oncology1477-78192009-03-01713510.1186/1477-7819-7-35A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational studyVijaykumar DKPavithran KHiran KRSharma Shekhar<p>Abstract</p> <p>Background</p> <p>Interest in translational studies aimed at investigating biologic markers in predicting response to primary chemotherapy (PCT) in breast cancer has progressively increased. We conducted a pilot study to evaluate feasibility of evaluating biomarkers of response to PCT at one & 21 days after first cycle.</p> <p>Methods</p> <p>Adult, non-pregnant, non-lactating women with histologically confirmed infiltrating duct carcinoma underwent serial core biopsies after first cycle of PCT and these were scored for <it>Ki</it>-67, <it>Bcl</it>-2 and <it>Caspase</it>-3 using immunohistochemistry.</p> <p>Results</p> <p>We recruited 30 patients with a mean age of 51 years. We were successful 95.6% times in performing a core biopsy and of these 84.6% had adequate tissue in the cores harvested. After a mean of 4 cycles of PCT, 26 patients underwent surgery and good response was noted in 9 patients (30%) using Miller-Payne criteria. There was a trend noted in all markers, which appeared different in those with good response and poor response. Good responders had significantly higher <it>Ki-67 </it>and significantly lower <it>Bcl</it>-2 at baseline and a significant decrease in <it>Ki-67 </it>and <it>Caspase-3 </it>at 21 days after the first chemotherapy.</p> <p>Conclusion</p> <p>We report a detectable change in biomarkers as early as 24–48 hours after the first chemotherapy along with a definite trend in change that can possibly be used to predict response to chemotherapy in an individual patient. The statistical significance and clinical utility of such changes needs to be evaluated and confirmed in larger trials.</p>http://www.wjso.com/content/7/1/35 |
| spellingShingle | Vijaykumar DK Pavithran K Hiran KR Sharma Shekhar A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study World Journal of Surgical Oncology |
| title | A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study |
| title_full | A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study |
| title_fullStr | A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study |
| title_full_unstemmed | A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study |
| title_short | A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study |
| title_sort | pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day 21 days after first cycle of chemotherapy in carcinoma of breast a prospective non randomized observational study |
| url | http://www.wjso.com/content/7/1/35 |
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