Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report
Abstract Background Dupilumab-induced ocular surface disease (DIOSD) has been reported in patients with atopic dermatitis treated with dupilumab, and has been recognized as an adverse event of dupilumab. Our objective was to describe two cases of DIOSD with alterations in eotaxin-2 and interleukin (...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-022-00727-6 |
| _version_ | 1797998313095561216 |
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| author | Rumi Adachi Jun Shoji Akira Hirota Akiko Tomioka Yukiko Tonozuka Noriko Inada Satoru Yamagami |
| author_facet | Rumi Adachi Jun Shoji Akira Hirota Akiko Tomioka Yukiko Tonozuka Noriko Inada Satoru Yamagami |
| author_sort | Rumi Adachi |
| collection | DOAJ |
| description | Abstract Background Dupilumab-induced ocular surface disease (DIOSD) has been reported in patients with atopic dermatitis treated with dupilumab, and has been recognized as an adverse event of dupilumab. Our objective was to describe two cases of DIOSD with alterations in eotaxin-2 and interleukin (IL)-8 messenger ribonucleic acid (mRNA) expression on the ocular surface. Case presentation In the ocular surface test, specimens were collected from the patient's ocular surface, and eotaxin-2 and IL-8 mRNA levels in the specimens were measured using real-time polymerase chain reaction. The clinical score of ocular surface findings was quantified using a 5-5-5 exacerbation grading scale for allergic conjunctivitis. The first case was of a 27-year-old man who developed DIOSD 3 months after starting treatment with dupilumab injection for atopic dermatitis. After 5 weeks of topical instillation of tacrolimus ophthalmic suspension, the clinical score of ocular surface findings improved and IL-8 and eotaxin-2 mRNA expression levels gradually decreased. The second patient was a 55-year-old man who developed DIOSD 11 weeks after the start of treatment with dupilumab injection for atopic dermatitis. Four weeks after starting ophthalmological treatment with tacrolimus ophthalmic suspension, his clinical scores on ocular surface findings improved and IL-8 mRNA expression levels decreased. The ocular surface test in this case revealed increased expression levels of IL-8 mRNA on the ocular surface at the onset of DIOSD, which decreased with the improvement of objective findings. Conclusions DIOSD, which has been successfully treated with tacrolimus ophthalmic suspension, may involve IL-8-related inflammation in addition to type 2 inflammation. |
| first_indexed | 2024-04-11T10:46:43Z |
| format | Article |
| id | doaj.art-5974eaf3c1b54a7e9374f16761cd13cd |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-11T10:46:43Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-5974eaf3c1b54a7e9374f16761cd13cd2022-12-22T04:29:01ZengBMCAllergy, Asthma & Clinical Immunology1710-14922022-10-011811810.1186/s13223-022-00727-6Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case reportRumi Adachi0Jun Shoji1Akira Hirota2Akiko Tomioka3Yukiko Tonozuka4Noriko Inada5Satoru Yamagami6Division of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of MedicineAbstract Background Dupilumab-induced ocular surface disease (DIOSD) has been reported in patients with atopic dermatitis treated with dupilumab, and has been recognized as an adverse event of dupilumab. Our objective was to describe two cases of DIOSD with alterations in eotaxin-2 and interleukin (IL)-8 messenger ribonucleic acid (mRNA) expression on the ocular surface. Case presentation In the ocular surface test, specimens were collected from the patient's ocular surface, and eotaxin-2 and IL-8 mRNA levels in the specimens were measured using real-time polymerase chain reaction. The clinical score of ocular surface findings was quantified using a 5-5-5 exacerbation grading scale for allergic conjunctivitis. The first case was of a 27-year-old man who developed DIOSD 3 months after starting treatment with dupilumab injection for atopic dermatitis. After 5 weeks of topical instillation of tacrolimus ophthalmic suspension, the clinical score of ocular surface findings improved and IL-8 and eotaxin-2 mRNA expression levels gradually decreased. The second patient was a 55-year-old man who developed DIOSD 11 weeks after the start of treatment with dupilumab injection for atopic dermatitis. Four weeks after starting ophthalmological treatment with tacrolimus ophthalmic suspension, his clinical scores on ocular surface findings improved and IL-8 mRNA expression levels decreased. The ocular surface test in this case revealed increased expression levels of IL-8 mRNA on the ocular surface at the onset of DIOSD, which decreased with the improvement of objective findings. Conclusions DIOSD, which has been successfully treated with tacrolimus ophthalmic suspension, may involve IL-8-related inflammation in addition to type 2 inflammation.https://doi.org/10.1186/s13223-022-00727-6DupilumabConjunctivitisEotaxin-2Interleukin-8 |
| spellingShingle | Rumi Adachi Jun Shoji Akira Hirota Akiko Tomioka Yukiko Tonozuka Noriko Inada Satoru Yamagami Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report Allergy, Asthma & Clinical Immunology Dupilumab Conjunctivitis Eotaxin-2 Interleukin-8 |
| title | Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report |
| title_full | Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report |
| title_fullStr | Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report |
| title_full_unstemmed | Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report |
| title_short | Two cases of dupilumab-associated conjunctivitis with high expression of IL-8 mRNA on the ocular surface: a case report |
| title_sort | two cases of dupilumab associated conjunctivitis with high expression of il 8 mrna on the ocular surface a case report |
| topic | Dupilumab Conjunctivitis Eotaxin-2 Interleukin-8 |
| url | https://doi.org/10.1186/s13223-022-00727-6 |
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