Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022)
Abstract Background Global hypoxic‐ischemic brain injury (GHIBI) results in variable degrees of neurological dysfunction. Limited data exists to guide prognostication on likelihood of functional recovery. Hypothesis Prolonged duration of hypoxic‐ischemic insult and absence of neurological improvemen...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16790 |
| _version_ | 1797773405728014336 |
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| author | Abbe Harper Crawford Elsa Beltran Cecilia‐Gabriella Danciu Dylan Yaffy |
| author_facet | Abbe Harper Crawford Elsa Beltran Cecilia‐Gabriella Danciu Dylan Yaffy |
| author_sort | Abbe Harper Crawford |
| collection | DOAJ |
| description | Abstract Background Global hypoxic‐ischemic brain injury (GHIBI) results in variable degrees of neurological dysfunction. Limited data exists to guide prognostication on likelihood of functional recovery. Hypothesis Prolonged duration of hypoxic‐ischemic insult and absence of neurological improvement in the first 72 hours are negative prognostic indicators. Animals Ten clinical cases with GHIBI. Methods Retrospective case series describing 8 dogs and 2 cats with GHIBI, including clinical signs, treatment, and outcome. Results Six dogs and 2 cats experienced cardiopulmonary arrest or anesthetic complication in a veterinary hospital and were promptly resuscitated. Seven showed progressive neurological improvement within 72 hours of the hypoxic‐ischemic insult. Four fully recovered and 3 had residual neurological deficits. One dog presented comatose after resuscitation at the primary care practice. Magnetic resonance imaging confirmed diffuse cerebral cortical swelling and severe brainstem compression and the dog was euthanized. Two dogs suffered out‐of‐hospital cardiopulmonary arrest, secondary to a road traffic accident in 1 and laryngeal obstruction in the other. The first dog was euthanized after MRI that identified diffuse cerebral cortical swelling with severe brainstem compression. In the other dog, spontaneous circulation was recovered after 22 minutes of cardiopulmonary resuscitation. However, the dog remained blind, disorientated, and ambulatory tetraparetic with vestibular ataxia and was euthanized 58 days after presentation. Histopathological examination of the brain confirmed severe diffuse cerebral and cerebellar cortical necrosis. Conclusions and Clinical Importance Duration of hypoxic‐ischemic insult, diffuse brainstem involvement, MRI features, and rate of neurological recovery could provide indications of the likelihood of functional recovery after GHIBI. |
| first_indexed | 2024-03-12T22:05:01Z |
| format | Article |
| id | doaj.art-597569a59bbe4e2d9fd141cc5d60d017 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-12T22:05:01Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-597569a59bbe4e2d9fd141cc5d60d0172023-07-24T15:52:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-07-013741428143710.1111/jvim.16790Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022)Abbe Harper Crawford0Elsa Beltran1Cecilia‐Gabriella Danciu2Dylan Yaffy3Clinical Science and Services Royal Veterinary College, Hawkshead Lane, North Mymms Hatfield AL9 7TA United KingdomClinical Science and Services Royal Veterinary College, Hawkshead Lane, North Mymms Hatfield AL9 7TA United KingdomClinical Science and Services Royal Veterinary College, Hawkshead Lane, North Mymms Hatfield AL9 7TA United KingdomPathobiology and Population Sciences Royal Veterinary College, Hawkshead Lane, North Mymms Hatfield AL9 7TA United KingdomAbstract Background Global hypoxic‐ischemic brain injury (GHIBI) results in variable degrees of neurological dysfunction. Limited data exists to guide prognostication on likelihood of functional recovery. Hypothesis Prolonged duration of hypoxic‐ischemic insult and absence of neurological improvement in the first 72 hours are negative prognostic indicators. Animals Ten clinical cases with GHIBI. Methods Retrospective case series describing 8 dogs and 2 cats with GHIBI, including clinical signs, treatment, and outcome. Results Six dogs and 2 cats experienced cardiopulmonary arrest or anesthetic complication in a veterinary hospital and were promptly resuscitated. Seven showed progressive neurological improvement within 72 hours of the hypoxic‐ischemic insult. Four fully recovered and 3 had residual neurological deficits. One dog presented comatose after resuscitation at the primary care practice. Magnetic resonance imaging confirmed diffuse cerebral cortical swelling and severe brainstem compression and the dog was euthanized. Two dogs suffered out‐of‐hospital cardiopulmonary arrest, secondary to a road traffic accident in 1 and laryngeal obstruction in the other. The first dog was euthanized after MRI that identified diffuse cerebral cortical swelling with severe brainstem compression. In the other dog, spontaneous circulation was recovered after 22 minutes of cardiopulmonary resuscitation. However, the dog remained blind, disorientated, and ambulatory tetraparetic with vestibular ataxia and was euthanized 58 days after presentation. Histopathological examination of the brain confirmed severe diffuse cerebral and cerebellar cortical necrosis. Conclusions and Clinical Importance Duration of hypoxic‐ischemic insult, diffuse brainstem involvement, MRI features, and rate of neurological recovery could provide indications of the likelihood of functional recovery after GHIBI.https://doi.org/10.1111/jvim.16790caninecerebralfelinehypoxiaischemic |
| spellingShingle | Abbe Harper Crawford Elsa Beltran Cecilia‐Gabriella Danciu Dylan Yaffy Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) Journal of Veterinary Internal Medicine canine cerebral feline hypoxia ischemic |
| title | Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) |
| title_full | Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) |
| title_fullStr | Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) |
| title_full_unstemmed | Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) |
| title_short | Clinical presentation, diagnosis, treatment, and outcome in 8 dogs and 2 cats with global hypoxic‐ischemic brain injury (2010‐2022) |
| title_sort | clinical presentation diagnosis treatment and outcome in 8 dogs and 2 cats with global hypoxic ischemic brain injury 2010 2022 |
| topic | canine cerebral feline hypoxia ischemic |
| url | https://doi.org/10.1111/jvim.16790 |
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