Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis
In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding and unexpected intraoperative bleeding which is likely to increase the risk of complications and surgical failure. High expansion sponges are effective clinical practice for the treatment of wound bleeding...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23001263 |
| _version_ | 1797203911309787136 |
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| author | Akriti Nepal Huong D.N. Tran Nam-Trung Nguyen Hang Thu Ta |
| author_facet | Akriti Nepal Huong D.N. Tran Nam-Trung Nguyen Hang Thu Ta |
| author_sort | Akriti Nepal |
| collection | DOAJ |
| description | In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding and unexpected intraoperative bleeding which is likely to increase the risk of complications and surgical failure. High expansion sponges are effective clinical practice for the treatment of wound bleeding (irregular/deep/narrow) that are caused by capillaries, veins and even arterioles as they possess a high liquid absorption ratio so can absorb blood platelets easily in comparison with traditional haemostasis treatments, which involve compression, ligation, or electrical coagulation etc. When in contact with blood, haemostatic sponges can cause platelet adhesion, aggregation, and thrombosis, preventing blood from flowing out from wounds, triggering the release of coagulation factors, causing the blood to form a stable polymerized fibre protein, forming blood clots, and achieving the goal of wound bleeding control. Haemostatic sponges are found in a variety of shapes and sizes. The aim of this review is to facilitate an overview of recent research around haemostatic sponge materials, products, and technology. This paper reviews the synthesis, properties, and characteristics of haemostatic sponges, together with the haemostasis mechanisms of haemostatic sponges (composite materials), such as chitosan, cellulose, gelatin, starch, graphene oxide, hyaluronic acid, alginate, polyethylene glycol, silk fibroin, synthetic polymers silver nanoparticles, zinc oxide nanoparticles, mesoporous silica nanoparticles, and silica nanoparticles. Also, this paper reviews commercial sponges and their properties. In addition to this, we discuss various in-vitro/in-vivo approaches for the evaluation of the effect of sponges on haemostasis. |
| first_indexed | 2024-03-13T04:26:50Z |
| format | Article |
| id | doaj.art-59764d8117df4a83a846b21757919930 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:26:51Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-59764d8117df4a83a846b217579199302024-04-16T21:35:18ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-09-0127231256Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasisAkriti Nepal0Huong D.N. Tran1Nam-Trung Nguyen2Hang Thu Ta3Queensland Micro-and Nanotechnology Centre, Griffith University, Nathan, Queensland, 4111, AustraliaQueensland Micro-and Nanotechnology Centre, Griffith University, Nathan, Queensland, 4111, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, 4072, AustraliaQueensland Micro-and Nanotechnology Centre, Griffith University, Nathan, Queensland, 4111, AustraliaQueensland Micro-and Nanotechnology Centre, Griffith University, Nathan, Queensland, 4111, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, 4072, Australia; Bioscience Discipline, School of Environment and Science, Griffith University, Nathan, Queensland, 4111, Australia; Corresponding author. Bioscience Department, School of Environment and Science, Griffith University, Nathan Campus, Brisbane, QLD, 4111, Australia..In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding and unexpected intraoperative bleeding which is likely to increase the risk of complications and surgical failure. High expansion sponges are effective clinical practice for the treatment of wound bleeding (irregular/deep/narrow) that are caused by capillaries, veins and even arterioles as they possess a high liquid absorption ratio so can absorb blood platelets easily in comparison with traditional haemostasis treatments, which involve compression, ligation, or electrical coagulation etc. When in contact with blood, haemostatic sponges can cause platelet adhesion, aggregation, and thrombosis, preventing blood from flowing out from wounds, triggering the release of coagulation factors, causing the blood to form a stable polymerized fibre protein, forming blood clots, and achieving the goal of wound bleeding control. Haemostatic sponges are found in a variety of shapes and sizes. The aim of this review is to facilitate an overview of recent research around haemostatic sponge materials, products, and technology. This paper reviews the synthesis, properties, and characteristics of haemostatic sponges, together with the haemostasis mechanisms of haemostatic sponges (composite materials), such as chitosan, cellulose, gelatin, starch, graphene oxide, hyaluronic acid, alginate, polyethylene glycol, silk fibroin, synthetic polymers silver nanoparticles, zinc oxide nanoparticles, mesoporous silica nanoparticles, and silica nanoparticles. Also, this paper reviews commercial sponges and their properties. In addition to this, we discuss various in-vitro/in-vivo approaches for the evaluation of the effect of sponges on haemostasis.http://www.sciencedirect.com/science/article/pii/S2452199X23001263Haemostatic spongeCharacteristicsMechanismHaemostasisNanoparticles |
| spellingShingle | Akriti Nepal Huong D.N. Tran Nam-Trung Nguyen Hang Thu Ta Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis Bioactive Materials Haemostatic sponge Characteristics Mechanism Haemostasis Nanoparticles |
| title | Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis |
| title_full | Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis |
| title_fullStr | Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis |
| title_full_unstemmed | Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis |
| title_short | Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis |
| title_sort | advances in haemostatic sponges characteristics and the underlying mechanisms for rapid haemostasis |
| topic | Haemostatic sponge Characteristics Mechanism Haemostasis Nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23001263 |
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