Migrasome: a new functional extracellular vesicle
Abstract Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. I...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-10-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01673-x |
| _version_ | 1827635550709874688 |
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| author | Xide Zhang Liuhuan Yao Yuanyuan Meng Bailong Li Yanyong Yang Fu Gao |
| author_facet | Xide Zhang Liuhuan Yao Yuanyuan Meng Bailong Li Yanyong Yang Fu Gao |
| author_sort | Xide Zhang |
| collection | DOAJ |
| description | Abstract Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays important roles in various fields especially in the information exchange between cells. The discovery of migrasome, as an important supplement to the extracellular vesicle system, provides new mechanisms and targets for comprehending various biological or pathological processes. In this article, we will review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases. This review also creates prospects for the possible research directions and clinical applications of migrasomes in the future. |
| first_indexed | 2024-03-09T15:29:14Z |
| format | Article |
| id | doaj.art-59766f8973234c22a16232c120566189 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-09T15:29:14Z |
| publishDate | 2023-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-59766f8973234c22a16232c1205661892023-11-26T12:21:02ZengNature Publishing GroupCell Death Discovery2058-77162023-10-01911710.1038/s41420-023-01673-xMigrasome: a new functional extracellular vesicleXide Zhang0Liuhuan Yao1Yuanyuan Meng2Bailong Li3Yanyong Yang4Fu Gao5Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical UniversityDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical UniversityNaval Medical University, Department of Traditional Chinese Medicine, Affiliated Hospital 1Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical UniversityDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical UniversityDepartment of Radiation Medicine, Faculty of Naval Medicine, Naval Medical UniversityAbstract Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis depends on the migration process. It is generated in a variety of cells such as immune cells, metastatic tumor cells, other special functional cells like podocytes and cells in developing organisms. It plays important roles in various fields especially in the information exchange between cells. The discovery of migrasome, as an important supplement to the extracellular vesicle system, provides new mechanisms and targets for comprehending various biological or pathological processes. In this article, we will review the discovery, structure, distribution, detection, biogenesis, and removal of migrasomes and mainly focus on summarizing its biological functions in cell-to-cell communication, homeostatic maintenance, embryonic development and multiple diseases. This review also creates prospects for the possible research directions and clinical applications of migrasomes in the future.https://doi.org/10.1038/s41420-023-01673-x |
| spellingShingle | Xide Zhang Liuhuan Yao Yuanyuan Meng Bailong Li Yanyong Yang Fu Gao Migrasome: a new functional extracellular vesicle Cell Death Discovery |
| title | Migrasome: a new functional extracellular vesicle |
| title_full | Migrasome: a new functional extracellular vesicle |
| title_fullStr | Migrasome: a new functional extracellular vesicle |
| title_full_unstemmed | Migrasome: a new functional extracellular vesicle |
| title_short | Migrasome: a new functional extracellular vesicle |
| title_sort | migrasome a new functional extracellular vesicle |
| url | https://doi.org/10.1038/s41420-023-01673-x |
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