Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy
Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing dialysis due to kidney failure. Lifes...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9228/25060_CE[Ra1]_F(DK)_PF1(RB_DK)_PFA(DK)_PF2(NE_DK).pdf |
| Summary: | Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated
with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing
dialysis due to kidney failure. Lifestyle modifications; cessation of smoking, optimum control of blood glucose, blood pressure and
lipids are required to reduce the progression of Diabetic Kidney Disease (DKD). Presently, Dipeptidyl peptidase-4 (DPP-4) inhibitors are
preferred in the management of T2DM due to their established efficacy; favorable tolerability including, low risk of hypoglycaemia; weight
neutrality and convenient once-a-day dosage. Present evidence suggests that linagliptin and teneligliptin can be used safely without
dose adjustments in patients with T2DM with renal impairment, including End Stage Renal Disease (ESRD). There is a limited data
about teneligliptin particularly in T2DM patients with renal impairment. The objective of this review is to evaluate efficacy and safety of
teneligliptin in T2DM patients with renal impairment, in order to assess the current place in therapy and future prospects of teneligliptin.
Reported evidence suggests that teneligliptin has consistent pharmacokinetic in mild, moderate, severe or ESRD, without any need for
dose adjustments. Limited data from small sample studies of teneligliptin in DKD patients reported significant improvements in glycaemic
parameters. Additionally, there is an improvement in kidney parameters like glycated albumin, urinary albumin and eGFR. There is an
evidence of reduction in biomarkers of kidney impairment like P-selectin (sP-selectin), Platelet-Derived Microparticles (PDMPs) and
Plasminogen Activator Inhibitor 1 (PAI-1). Clinical significance of these will be known in near future. Thus, teneligliptin has an important
place of therapy in the management of T2DM with renal impairment. |
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| ISSN: | 2249-782X 0973-709X |