Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy
Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing dialysis due to kidney failure. Lifes...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9228/25060_CE[Ra1]_F(DK)_PF1(RB_DK)_PFA(DK)_PF2(NE_DK).pdf |
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| author | Mohammed Abubaker Preetesh Mishra Onkar C. Swami |
| author_facet | Mohammed Abubaker Preetesh Mishra Onkar C. Swami |
| author_sort | Mohammed Abubaker |
| collection | DOAJ |
| description | Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated
with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing
dialysis due to kidney failure. Lifestyle modifications; cessation of smoking, optimum control of blood glucose, blood pressure and
lipids are required to reduce the progression of Diabetic Kidney Disease (DKD). Presently, Dipeptidyl peptidase-4 (DPP-4) inhibitors are
preferred in the management of T2DM due to their established efficacy; favorable tolerability including, low risk of hypoglycaemia; weight
neutrality and convenient once-a-day dosage. Present evidence suggests that linagliptin and teneligliptin can be used safely without
dose adjustments in patients with T2DM with renal impairment, including End Stage Renal Disease (ESRD). There is a limited data
about teneligliptin particularly in T2DM patients with renal impairment. The objective of this review is to evaluate efficacy and safety of
teneligliptin in T2DM patients with renal impairment, in order to assess the current place in therapy and future prospects of teneligliptin.
Reported evidence suggests that teneligliptin has consistent pharmacokinetic in mild, moderate, severe or ESRD, without any need for
dose adjustments. Limited data from small sample studies of teneligliptin in DKD patients reported significant improvements in glycaemic
parameters. Additionally, there is an improvement in kidney parameters like glycated albumin, urinary albumin and eGFR. There is an
evidence of reduction in biomarkers of kidney impairment like P-selectin (sP-selectin), Platelet-Derived Microparticles (PDMPs) and
Plasminogen Activator Inhibitor 1 (PAI-1). Clinical significance of these will be known in near future. Thus, teneligliptin has an important
place of therapy in the management of T2DM with renal impairment. |
| first_indexed | 2024-12-12T13:53:42Z |
| format | Article |
| id | doaj.art-597988b7586944668a7de6da27945d75 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T13:53:42Z |
| publishDate | 2017-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-597988b7586944668a7de6da27945d752022-12-22T00:22:31ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-01-01111OE05OE0910.7860/JCDR/2017/25060.9228Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in TherapyMohammed Abubaker0Preetesh Mishra1Onkar C. Swami2Professor, Department of Medicine, Deccan College of Medical Sciences, Hyderabad, Telangana, India.Assistant Manager, Medical Services, Unichem Laboratories Ltd., Mumbai, Maharashtra, India.Head of Medical Services, Unichem Laboratories Ltd., Mumbai, Maharashtra, India.Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing dialysis due to kidney failure. Lifestyle modifications; cessation of smoking, optimum control of blood glucose, blood pressure and lipids are required to reduce the progression of Diabetic Kidney Disease (DKD). Presently, Dipeptidyl peptidase-4 (DPP-4) inhibitors are preferred in the management of T2DM due to their established efficacy; favorable tolerability including, low risk of hypoglycaemia; weight neutrality and convenient once-a-day dosage. Present evidence suggests that linagliptin and teneligliptin can be used safely without dose adjustments in patients with T2DM with renal impairment, including End Stage Renal Disease (ESRD). There is a limited data about teneligliptin particularly in T2DM patients with renal impairment. The objective of this review is to evaluate efficacy and safety of teneligliptin in T2DM patients with renal impairment, in order to assess the current place in therapy and future prospects of teneligliptin. Reported evidence suggests that teneligliptin has consistent pharmacokinetic in mild, moderate, severe or ESRD, without any need for dose adjustments. Limited data from small sample studies of teneligliptin in DKD patients reported significant improvements in glycaemic parameters. Additionally, there is an improvement in kidney parameters like glycated albumin, urinary albumin and eGFR. There is an evidence of reduction in biomarkers of kidney impairment like P-selectin (sP-selectin), Platelet-Derived Microparticles (PDMPs) and Plasminogen Activator Inhibitor 1 (PAI-1). Clinical significance of these will be known in near future. Thus, teneligliptin has an important place of therapy in the management of T2DM with renal impairment.https://jcdr.net/articles/PDF/9228/25060_CE[Ra1]_F(DK)_PF1(RB_DK)_PFA(DK)_PF2(NE_DK).pdfdiabetes mellitusdipeptidyl peptidase-4 inhibitorrenal impairment |
| spellingShingle | Mohammed Abubaker Preetesh Mishra Onkar C. Swami Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy Journal of Clinical and Diagnostic Research diabetes mellitus dipeptidyl peptidase-4 inhibitor renal impairment |
| title | Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy |
| title_full | Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy |
| title_fullStr | Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy |
| title_full_unstemmed | Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy |
| title_short | Teneligliptin in Management of Diabetic Kidney Disease: A Review of Place in Therapy |
| title_sort | teneligliptin in management of diabetic kidney disease a review of place in therapy |
| topic | diabetes mellitus dipeptidyl peptidase-4 inhibitor renal impairment |
| url | https://jcdr.net/articles/PDF/9228/25060_CE[Ra1]_F(DK)_PF1(RB_DK)_PFA(DK)_PF2(NE_DK).pdf |
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