Exploring the landscape of immunotherapy approaches in sarcomas
Sarcomas comprise a heterogenous group of malignancies, of more than 100 different entities, arising from mesenchymal tissue, and accounting for 1% of adult malignancies. Surgery, radiotherapy and systemic therapy constitute the therapeutic armamentarium against sarcomas, with surgical excision and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1069963/full |
| _version_ | 1797959658556620800 |
|---|---|
| author | Pampina Pilavaki Pampina Pilavaki Myrofora Panagi Samia Arifi Robin L. Jones Robin L. Jones Triantafyllos Stylianopoulos Anastasia Constantinidou Anastasia Constantinidou Anastasia Constantinidou |
| author_facet | Pampina Pilavaki Pampina Pilavaki Myrofora Panagi Samia Arifi Robin L. Jones Robin L. Jones Triantafyllos Stylianopoulos Anastasia Constantinidou Anastasia Constantinidou Anastasia Constantinidou |
| author_sort | Pampina Pilavaki |
| collection | DOAJ |
| description | Sarcomas comprise a heterogenous group of malignancies, of more than 100 different entities, arising from mesenchymal tissue, and accounting for 1% of adult malignancies. Surgery, radiotherapy and systemic therapy constitute the therapeutic armamentarium against sarcomas, with surgical excision and conventional chemotherapy, remaining the mainstay of treatment for local and advanced disease, respectively. The prognosis for patients with metastatic disease is dismal and novel therapeutic approaches are urgently required to improve survival outcomes. Immunotherapy, is a rapidly evolving field in oncology, which has been successfully applied in multiple cancers to date. Immunomodulating antibodies, adoptive cellular therapy, cancer vaccines, and cytokines have been tested in patients with different types of sarcomas through clinical trials, pilot studies, retrospective and prospective studies. The results of these studies regarding the efficacy of different types of immunotherapies in sarcomas are conflicting, and the application of immunotherapy in daily clinical practice remains limited. Additional clinical studies are ongoing in an effort to delineate the role of immunotherapy in patients with specific sarcoma subtypes. |
| first_indexed | 2024-04-11T00:35:51Z |
| format | Article |
| id | doaj.art-597be88653fb4762bcd142788d6d18e7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T00:35:51Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-597be88653fb4762bcd142788d6d18e72023-01-06T19:19:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10699631069963Exploring the landscape of immunotherapy approaches in sarcomasPampina Pilavaki0Pampina Pilavaki1Myrofora Panagi2Samia Arifi3Robin L. Jones4Robin L. Jones5Triantafyllos Stylianopoulos6Anastasia Constantinidou7Anastasia Constantinidou8Anastasia Constantinidou9Medical School, University of Cyprus, Nicosia, CyprusMedical Oncology, Bank of Cyprus Oncology Center, Nicosia, CyprusCancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering University of Cyprus, Nicosia, CyprusMedical Oncology Department, Hassan II University Hospital/Faculty of Medicine and Pharmacy University of Sidi Mohamed Ben Abdellah, Fez, MoroccoSarcoma Unit, Royal Marsden National Health Service (NHS) Foundation Trust, London, London, United KingdomSarcoma Clinical Trial Unit, Institute of Cancer Research, London, United KingdomCancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering University of Cyprus, Nicosia, CyprusMedical School, University of Cyprus, Nicosia, CyprusMedical Oncology, Bank of Cyprus Oncology Center, Nicosia, CyprusCyprus Cancer Research Institute, Nicosia, CyprusSarcomas comprise a heterogenous group of malignancies, of more than 100 different entities, arising from mesenchymal tissue, and accounting for 1% of adult malignancies. Surgery, radiotherapy and systemic therapy constitute the therapeutic armamentarium against sarcomas, with surgical excision and conventional chemotherapy, remaining the mainstay of treatment for local and advanced disease, respectively. The prognosis for patients with metastatic disease is dismal and novel therapeutic approaches are urgently required to improve survival outcomes. Immunotherapy, is a rapidly evolving field in oncology, which has been successfully applied in multiple cancers to date. Immunomodulating antibodies, adoptive cellular therapy, cancer vaccines, and cytokines have been tested in patients with different types of sarcomas through clinical trials, pilot studies, retrospective and prospective studies. The results of these studies regarding the efficacy of different types of immunotherapies in sarcomas are conflicting, and the application of immunotherapy in daily clinical practice remains limited. Additional clinical studies are ongoing in an effort to delineate the role of immunotherapy in patients with specific sarcoma subtypes.https://www.frontiersin.org/articles/10.3389/fonc.2022.1069963/fullsarcomabone sarcomasoft tissue sarcomaimmunotherapycheckpoint inhibitorsundifferentiated pleomorphic sarcoma UPS |
| spellingShingle | Pampina Pilavaki Pampina Pilavaki Myrofora Panagi Samia Arifi Robin L. Jones Robin L. Jones Triantafyllos Stylianopoulos Anastasia Constantinidou Anastasia Constantinidou Anastasia Constantinidou Exploring the landscape of immunotherapy approaches in sarcomas Frontiers in Oncology sarcoma bone sarcoma soft tissue sarcoma immunotherapy checkpoint inhibitors undifferentiated pleomorphic sarcoma UPS |
| title | Exploring the landscape of immunotherapy approaches in sarcomas |
| title_full | Exploring the landscape of immunotherapy approaches in sarcomas |
| title_fullStr | Exploring the landscape of immunotherapy approaches in sarcomas |
| title_full_unstemmed | Exploring the landscape of immunotherapy approaches in sarcomas |
| title_short | Exploring the landscape of immunotherapy approaches in sarcomas |
| title_sort | exploring the landscape of immunotherapy approaches in sarcomas |
| topic | sarcoma bone sarcoma soft tissue sarcoma immunotherapy checkpoint inhibitors undifferentiated pleomorphic sarcoma UPS |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1069963/full |
| work_keys_str_mv | AT pampinapilavaki exploringthelandscapeofimmunotherapyapproachesinsarcomas AT pampinapilavaki exploringthelandscapeofimmunotherapyapproachesinsarcomas AT myroforapanagi exploringthelandscapeofimmunotherapyapproachesinsarcomas AT samiaarifi exploringthelandscapeofimmunotherapyapproachesinsarcomas AT robinljones exploringthelandscapeofimmunotherapyapproachesinsarcomas AT robinljones exploringthelandscapeofimmunotherapyapproachesinsarcomas AT triantafyllosstylianopoulos exploringthelandscapeofimmunotherapyapproachesinsarcomas AT anastasiaconstantinidou exploringthelandscapeofimmunotherapyapproachesinsarcomas AT anastasiaconstantinidou exploringthelandscapeofimmunotherapyapproachesinsarcomas AT anastasiaconstantinidou exploringthelandscapeofimmunotherapyapproachesinsarcomas |