Liposomal Encapsulated FSC231, a PICK1 Inhibitor, Prevents the Ischemia/Reperfusion-Induced Degradation of GluA2-Containing AMPA Receptors

Liposomal Encapsulated FSC231, a PICK1 Inhibitor, Prevents the Ischemia/Reperfusion-Induced Degradation of GluA2-Containing AMPA Receptors

Strokes remain one of the leading causes of disability within the United States. Despite an enormous amount of research effort within the scientific community, very few therapeutics are available for stroke patients. Cytotoxic accumulation of intracellular calcium is a well-studied phenomenon that o...

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Bibliographic Details
Main Authors: Lindsay M. Achzet, Fanny Astruc-Diaz, Phillip H. Beske, Nicholas R. Natale, Travis T. Denton, Darrell A. Jackson
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
ischemic/reperfusion injury
protein interacting with C kinase 1 (PICK1)
AMPA receptor
FSC231
liposome
drug delivery system
Online Access:https://www.mdpi.com/1999-4923/13/5/636

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