Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission
A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synapti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6423 |
| _version_ | 1797554700755664896 |
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| author | Ayrat U. Ziganshin Adel E. Khairullin Charles H. V. Hoyle Sergey N. Grishin |
| author_facet | Ayrat U. Ziganshin Adel E. Khairullin Charles H. V. Hoyle Sergey N. Grishin |
| author_sort | Ayrat U. Ziganshin |
| collection | DOAJ |
| description | A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated. As usual, the P2-receptor-mediated influence is minimal under physiological conditions, but it becomes very important in some pathophysiological situations such as hypothermia, stress, or ischemia. There are some data demonstrating the same in neuromuscular transmission. It is suggested that the role of endogenous purines is primarily to provide a safety factor for the efficiency of cholinergic neuromuscular transmission. |
| first_indexed | 2024-03-10T16:35:47Z |
| format | Article |
| id | doaj.art-597cb286d8e04499847b1e07c18d2025 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:35:47Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-597cb286d8e04499847b1e07c18d20252023-11-20T12:28:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117642310.3390/ijms21176423Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular TransmissionAyrat U. Ziganshin0Adel E. Khairullin1Charles H. V. Hoyle2Sergey N. Grishin3Department of Pharmacology, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, RussiaDepartment of Biochemistry, Laboratory and Clinical Diagnostics, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, RussiaDepartment of Pharmacology, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, RussiaDepartment of Medical and Biological Physics with Computer Science and Medical Equipment, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, RussiaA review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated. As usual, the P2-receptor-mediated influence is minimal under physiological conditions, but it becomes very important in some pathophysiological situations such as hypothermia, stress, or ischemia. There are some data demonstrating the same in neuromuscular transmission. It is suggested that the role of endogenous purines is primarily to provide a safety factor for the efficiency of cholinergic neuromuscular transmission.https://www.mdpi.com/1422-0067/21/17/6423neuromuscular junctionATPadenosinepurinessynaptic modulation |
| spellingShingle | Ayrat U. Ziganshin Adel E. Khairullin Charles H. V. Hoyle Sergey N. Grishin Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission International Journal of Molecular Sciences neuromuscular junction ATP adenosine purines synaptic modulation |
| title | Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission |
| title_full | Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission |
| title_fullStr | Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission |
| title_full_unstemmed | Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission |
| title_short | Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission |
| title_sort | modulatory roles of atp and adenosine in cholinergic neuromuscular transmission |
| topic | neuromuscular junction ATP adenosine purines synaptic modulation |
| url | https://www.mdpi.com/1422-0067/21/17/6423 |
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