State of antioxidant system of rat thymocytes in experimental ulcerogenesis
Features of free radical processes and their impact on the implementation of immunocompetent cells of their functions under conditions of peptic ulcer are insufficiently studied today. Reduced activity of catalase 1.7 and 3.4 times and that of glutathione peroxidise ~ 2.0 times, accordingly, were o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2014-08-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Kovaleva_4_14.pdf |
| _version_ | 1827614099945553920 |
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| author | V. A. Kovaleva L. M. Gaida A. E. Shevchenko D. V. Shelest L. I. Ostapchenko |
| author_facet | V. A. Kovaleva L. M. Gaida A. E. Shevchenko D. V. Shelest L. I. Ostapchenko |
| author_sort | V. A. Kovaleva |
| collection | DOAJ |
| description | Features of free radical processes and their impact on the implementation of immunocompetent cells of their functions under conditions of peptic ulcer are insufficiently studied today. Reduced activity of catalase 1.7 and 3.4 times and that of glutathione peroxidise ~ 2.0 times, accordingly, were observed in both models of gastric ulceration (stress ulcer and ethanol one). Enzymatic activity of superoxide dismutase decreased 1.5 times and activity of glutathione transferase increased 1.8 times in the stress model in contrast to the ethanol model of stomach ulcer. Obtained results indicate the exhaustion of antioxidant system in rats’ thymocytes under experimental ulcerogenesis. These data confirm complex negative effect of ulcer on the organism. |
| first_indexed | 2024-03-09T08:49:57Z |
| format | Article |
| id | doaj.art-597cf7b4e85a485fb8b71bdd55522679 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:49:57Z |
| publishDate | 2014-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-597cf7b4e85a485fb8b71bdd555226792023-12-02T14:35:55ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032014-08-0186412613110.15407/ubj86.04.126State of antioxidant system of rat thymocytes in experimental ulcerogenesisV. A. Kovaleva0 L. M. Gaida1 A. E. Shevchenko2 D. V. Shelest3L. I. Ostapchenko4Educational and Scientific Centre Institute of Biology,Taras Shevchenko Kyiv National University, UkraineEducational and Scientific Centre Institute of Biology,Taras Shevchenko Kyiv National University, UkraineEducational and Scientific Centre Institute of Biology,Taras Shevchenko Kyiv National University, UkraineEducational and Scientific Centre Institute of Biology,Taras Shevchenko Kyiv National University, UkraineEducational and Scientific Centre Institute of Biology,Taras Shevchenko Kyiv National University, UkraineFeatures of free radical processes and their impact on the implementation of immunocompetent cells of their functions under conditions of peptic ulcer are insufficiently studied today. Reduced activity of catalase 1.7 and 3.4 times and that of glutathione peroxidise ~ 2.0 times, accordingly, were observed in both models of gastric ulceration (stress ulcer and ethanol one). Enzymatic activity of superoxide dismutase decreased 1.5 times and activity of glutathione transferase increased 1.8 times in the stress model in contrast to the ethanol model of stomach ulcer. Obtained results indicate the exhaustion of antioxidant system in rats’ thymocytes under experimental ulcerogenesis. These data confirm complex negative effect of ulcer on the organism.http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Kovaleva_4_14.pdfantioxidant enzymescatalaseglutathione peroxidaseglutathione transferasemodel of ethanol and stress stomach ulcersuperoxide dismutase |
| spellingShingle | V. A. Kovaleva L. M. Gaida A. E. Shevchenko D. V. Shelest L. I. Ostapchenko State of antioxidant system of rat thymocytes in experimental ulcerogenesis The Ukrainian Biochemical Journal antioxidant enzymes catalase glutathione peroxidase glutathione transferase model of ethanol and stress stomach ulcer superoxide dismutase |
| title | State of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| title_full | State of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| title_fullStr | State of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| title_full_unstemmed | State of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| title_short | State of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| title_sort | state of antioxidant system of rat thymocytes in experimental ulcerogenesis |
| topic | antioxidant enzymes catalase glutathione peroxidase glutathione transferase model of ethanol and stress stomach ulcer superoxide dismutase |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Kovaleva_4_14.pdf |
| work_keys_str_mv | AT vakovaleva stateofantioxidantsystemofratthymocytesinexperimentalulcerogenesis AT lmgaida stateofantioxidantsystemofratthymocytesinexperimentalulcerogenesis AT aeshevchenko stateofantioxidantsystemofratthymocytesinexperimentalulcerogenesis AT dvshelest stateofantioxidantsystemofratthymocytesinexperimentalulcerogenesis AT liostapchenko stateofantioxidantsystemofratthymocytesinexperimentalulcerogenesis |