Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report
Tuberculosis (Tb) is, currently, the deadliest infectious disease and is caused by organisms of the Mycobacterium tuberculosis complex; the most common clinical manifestation is pulmonary involvement; however, it can also manifest as extrapulmonary affection in immunocompromised patients, especially...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Emergency Department of Hospital San Pedro (Logroño, Spain)
2023-09-01
|
| Series: | Iberoamerican Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2023.0030 |
| _version_ | 1797663335383040000 |
|---|---|
| author | Vianey Guadalupe Tellez Bolaños Alejandra Lizbeth Salinas Atriano Karla Daniela Salgado Guizar Louis Fernando Robles Fernandez Francisco Javier Pedraza Murillo Roberto Camarena Álvarez |
| author_facet | Vianey Guadalupe Tellez Bolaños Alejandra Lizbeth Salinas Atriano Karla Daniela Salgado Guizar Louis Fernando Robles Fernandez Francisco Javier Pedraza Murillo Roberto Camarena Álvarez |
| author_sort | Vianey Guadalupe Tellez Bolaños |
| collection | DOAJ |
| description | Tuberculosis (Tb) is, currently, the deadliest infectious disease and is caused by organisms of the Mycobacterium tuberculosis complex; the most common clinical manifestation is pulmonary involvement; however, it can also manifest as extrapulmonary affection in immunocompromised patients, especially in patients with human immunodeficiency virus (HIV) chronic infection up to 20% of the cases, despite being on adequate antiretroviral therapy. Within the extrapulmonary manifestations, affection of the central nervous system by hematogenous dissemination occurs in up to 5%, however, the finding of tuberculomas, which is a form of central nervous system involvement, is rare and an important cause in secondary hydrocephalus in these patients. We present the case of a male patient with a history of HIV infection and meningeal tuberculosis, who presented dysfunction of his ventriculoperitoneal shunt and in the imaging study multiple tuberculomas were found, a cerebrospinal fluid study was performed where multi-resistant tuberculosis (MDR) was documented, therefore despite adequate management of Tb, tuberculomas developed. |
| first_indexed | 2024-03-11T19:13:01Z |
| format | Article |
| id | doaj.art-597d0eb8b02342d5bc2317e5211f893c |
| institution | Directory Open Access Journal |
| issn | 2695-5075 |
| language | English |
| last_indexed | 2024-03-11T19:13:01Z |
| publishDate | 2023-09-01 |
| publisher | Emergency Department of Hospital San Pedro (Logroño, Spain) |
| record_format | Article |
| series | Iberoamerican Journal of Medicine |
| spelling | doaj.art-597d0eb8b02342d5bc2317e5211f893c2023-10-09T09:28:45ZengEmergency Department of Hospital San Pedro (Logroño, Spain)Iberoamerican Journal of Medicine2695-50752023-09-015418118510.53986/ibjm.2023.0030Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case reportVianey Guadalupe Tellez Bolaños0https://orcid.org/0000-0003-4613-3805Alejandra Lizbeth Salinas Atriano1https://orcid.org/0009-0006-2337-1287Karla Daniela Salgado Guizar2https://orcid.org/0009-0000-9427-8633Louis Fernando Robles Fernandez3https://orcid.org/0000-0002-0387-8797Francisco Javier Pedraza Murillo4https://orcid.org/0009-0003-5620-7174Roberto Camarena Álvarez5https://orcid.org/0000-0002-9984-1672Department of Internal Medicine, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute, Mexico City, MexicoDepartment of Internal Medicine, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute, Mexico City, MexicoDepartment of Internal Medicine, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute, Mexico City, MexicoDepartment of Internal Medicine, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute, Mexico City, MexicoDepartment of Internal Medicine, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute, Mexico City, MexicoDiagnostic and Therapeutic Department, Hospital General del Estado de Sonora Dr. Ernesto Ramos Bours, Sonora, MexicoTuberculosis (Tb) is, currently, the deadliest infectious disease and is caused by organisms of the Mycobacterium tuberculosis complex; the most common clinical manifestation is pulmonary involvement; however, it can also manifest as extrapulmonary affection in immunocompromised patients, especially in patients with human immunodeficiency virus (HIV) chronic infection up to 20% of the cases, despite being on adequate antiretroviral therapy. Within the extrapulmonary manifestations, affection of the central nervous system by hematogenous dissemination occurs in up to 5%, however, the finding of tuberculomas, which is a form of central nervous system involvement, is rare and an important cause in secondary hydrocephalus in these patients. We present the case of a male patient with a history of HIV infection and meningeal tuberculosis, who presented dysfunction of his ventriculoperitoneal shunt and in the imaging study multiple tuberculomas were found, a cerebrospinal fluid study was performed where multi-resistant tuberculosis (MDR) was documented, therefore despite adequate management of Tb, tuberculomas developed.https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2023.0030brain tuberculomasmulti-resistant tuberculosismagnetic resonance |
| spellingShingle | Vianey Guadalupe Tellez Bolaños Alejandra Lizbeth Salinas Atriano Karla Daniela Salgado Guizar Louis Fernando Robles Fernandez Francisco Javier Pedraza Murillo Roberto Camarena Álvarez Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report Iberoamerican Journal of Medicine brain tuberculomas multi-resistant tuberculosis magnetic resonance |
| title | Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report |
| title_full | Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report |
| title_fullStr | Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report |
| title_full_unstemmed | Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report |
| title_short | Cerebral tuberculomas: manifestation of extrapulmonary tuberculosis in an immunocompromised patient. A case report |
| title_sort | cerebral tuberculomas manifestation of extrapulmonary tuberculosis in an immunocompromised patient a case report |
| topic | brain tuberculomas multi-resistant tuberculosis magnetic resonance |
| url | https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2023.0030 |
| work_keys_str_mv | AT vianeyguadalupetellezbolanos cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport AT alejandralizbethsalinasatriano cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport AT karladanielasalgadoguizar cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport AT louisfernandoroblesfernandez cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport AT franciscojavierpedrazamurillo cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport AT robertocamarenaalvarez cerebraltuberculomasmanifestationofextrapulmonarytuberculosisinanimmunocompromisedpatientacasereport |