Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer
Due to the important role of N6-methyladenosine (m6A) in breast cancer, single nucleotide polymorphisms (SNPs) in genes with m6A modification may also be involved in breast cancer pathogenesis. In this study, we used a public genome-wide association study dataset to identify m6A-SNPs associated with...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Bioengineered |
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| Online Access: | http://dx.doi.org/10.1080/21655979.2021.1935406 |
| _version_ | 1798033903852716032 |
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| author | Zixue Xuan Yiwen Zhang Jinying Jiang Xiaowei Zheng Xiaoping Hu Xiuli Yang Yanfei Shao Guobing Zhang Ping Huang |
| author_facet | Zixue Xuan Yiwen Zhang Jinying Jiang Xiaowei Zheng Xiaoping Hu Xiuli Yang Yanfei Shao Guobing Zhang Ping Huang |
| author_sort | Zixue Xuan |
| collection | DOAJ |
| description | Due to the important role of N6-methyladenosine (m6A) in breast cancer, single nucleotide polymorphisms (SNPs) in genes with m6A modification may also be involved in breast cancer pathogenesis. In this study, we used a public genome-wide association study dataset to identify m6A-SNPs associated with breast cancer and to further explore their potential functions. We found 113 m6A-SNPs associated with breast cancer that reached the genome-wide suggestive threshold (5.0E-05), and 86 m6A-SNPs had eQTL signals. Only six genes were differentially expressed between controls and breast cancer cases in GEO datasets (GSE15852, GSE115144, and GSE109169), and the SNPs rs4829 and rs9610915 were located next to the m6A modification sites in the 3ʹUTRs of TOM1L1 and MAFF, respectively. In addition, we found that polyadenylate-binding protein cytoplasmic 1 might have a potential interaction with rs4829 (TOM1L1) and rs9610915 (MAFF). In summary, these findings indicated that the SNPs rs4829 and rs9610915 are potentially associated with breast cancer because they had eQTL signals, altered gene expression, and were located next to the m6A modification sites in the 3ʹUTRs of their coding genes. However, further studies are still needed to clarify how genetic variation affects the epigenetic modification, m6A, and its subsequent functions in the pathogenesis of breast cancer. |
| first_indexed | 2024-04-11T20:36:04Z |
| format | Article |
| id | doaj.art-597e6c693089413392965c7e69a57dc5 |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-04-11T20:36:04Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-597e6c693089413392965c7e69a57dc52022-12-22T04:04:21ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-011212389239710.1080/21655979.2021.19354061935406Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancerZixue Xuan0Yiwen Zhang1Jinying Jiang2Xiaowei Zheng3Xiaoping Hu4Xiuli Yang5Yanfei Shao6Guobing Zhang7Ping Huang8People’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegePeople’s Hospital of Hangzhou Medical CollegeDue to the important role of N6-methyladenosine (m6A) in breast cancer, single nucleotide polymorphisms (SNPs) in genes with m6A modification may also be involved in breast cancer pathogenesis. In this study, we used a public genome-wide association study dataset to identify m6A-SNPs associated with breast cancer and to further explore their potential functions. We found 113 m6A-SNPs associated with breast cancer that reached the genome-wide suggestive threshold (5.0E-05), and 86 m6A-SNPs had eQTL signals. Only six genes were differentially expressed between controls and breast cancer cases in GEO datasets (GSE15852, GSE115144, and GSE109169), and the SNPs rs4829 and rs9610915 were located next to the m6A modification sites in the 3ʹUTRs of TOM1L1 and MAFF, respectively. In addition, we found that polyadenylate-binding protein cytoplasmic 1 might have a potential interaction with rs4829 (TOM1L1) and rs9610915 (MAFF). In summary, these findings indicated that the SNPs rs4829 and rs9610915 are potentially associated with breast cancer because they had eQTL signals, altered gene expression, and were located next to the m6A modification sites in the 3ʹUTRs of their coding genes. However, further studies are still needed to clarify how genetic variation affects the epigenetic modification, m6A, and its subsequent functions in the pathogenesis of breast cancer.http://dx.doi.org/10.1080/21655979.2021.1935406m6asingle nucleotide polymorphisms (snps)breast cancergwasm6avar |
| spellingShingle | Zixue Xuan Yiwen Zhang Jinying Jiang Xiaowei Zheng Xiaoping Hu Xiuli Yang Yanfei Shao Guobing Zhang Ping Huang Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer Bioengineered m6a single nucleotide polymorphisms (snps) breast cancer gwas m6avar |
| title | Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer |
| title_full | Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer |
| title_fullStr | Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer |
| title_full_unstemmed | Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer |
| title_short | Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer |
| title_sort | integrative genomic analysis of n6 methyladenosine single nucleotide polymorphisms m6a snps associated with breast cancer |
| topic | m6a single nucleotide polymorphisms (snps) breast cancer gwas m6avar |
| url | http://dx.doi.org/10.1080/21655979.2021.1935406 |
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