High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer
BackgroundThis study investigates the potential impact of high progesterone (P) level on the day following human chorionic gonadotropin (HCG) injection on the clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET).MethodsRetrospective analysis was conducted on 6418 cycles of...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1372753/full |
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| author | Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Qiuyan Huang Qiuyan Huang Jiwei Huang Jiwei Huang Jiwei Huang Jiwei Huang Jinxiang Wu Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Pinxiu Huang Pinxiu Huang Pinxiu Huang Pinxiu Huang |
| author_facet | Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Qiuyan Huang Qiuyan Huang Jiwei Huang Jiwei Huang Jiwei Huang Jiwei Huang Jinxiang Wu Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Pinxiu Huang Pinxiu Huang Pinxiu Huang Pinxiu Huang |
| author_sort | Zhuo Liang |
| collection | DOAJ |
| description | BackgroundThis study investigates the potential impact of high progesterone (P) level on the day following human chorionic gonadotropin (HCG) injection on the clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET).MethodsRetrospective analysis was conducted on 6418 cycles of IVF-ET performed at Liuzhou Maternal and Child Health Hospital between August 2020 to December 2021. Excluding cycles with progesterone levels ≥1.5ng/ml on HCG injection, a total of 781 cycles were identified according to the standard, and they were divided into five groups according to the progesterone level on the day after HCG: Group A: progesterone level < 2.5 ng/ml (n = 128); Group B: 2.5 ng/ml ≤ progesterone level < 3.5 ng/ml (n = 174); Group C: 3.5 ng/ml ≤ progesterone level < 4.5 ng/ml (n = 153); Group D: 4.5 ng/ml ≤ progesterone level < 5.5 ng/ml (n = 132); Group E progesterone level ≥5.5 ng/ml(n=194). Comparative analyses of clinical data, including general clinical data, and clinical pregnancy outcomes such as clinical pregnancy rate, miscarriage rate, and live birth rate were performed among these groups.ResultsThere were significant differences in estradiol levels on HCG injection, but there were no differences in available embryo rate, clinical pregnancy rate, miscarriage rate, and live birth rate. Binary logistic regression analysis showed that there was no significant correlation between P level on the day after HCG injection and the live birth rate.ConclusionUnder the condition of low P level on HCG injection, high progesterone levels on the day after HCG injection does not affect the clinical pregnancy outcomes of IVF-ET. |
| first_indexed | 2024-04-24T08:51:57Z |
| format | Article |
| id | doaj.art-597edca018934c45b342086ca163546e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T08:51:57Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-597edca018934c45b342086ca163546e2024-04-16T09:37:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13727531372753High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transferZhuo Liang0Zhuo Liang1Zhuo Liang2Zhuo Liang3Zhuo Liang4Qiuyan Huang5Qiuyan Huang6Jiwei Huang7Jiwei Huang8Jiwei Huang9Jiwei Huang10Jinxiang Wu11Dingyuan Zeng12Dingyuan Zeng13Dingyuan Zeng14Dingyuan Zeng15Pinxiu Huang16Pinxiu Huang17Pinxiu Huang18Pinxiu Huang19Center of Reproductive Medicine, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaGuangxi Clinical Research Center for Obstetrics and Gynecology, Liuzhou, Guangxi, ChinaObstetrics and Gynecology Institute, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaCenter of Reproductive Medicine, Liuzhou Maternal and Child Health Hospital, Liuzhou, Guangxi, ChinaGraduate School, Guilin Medical College, Guilin, Guangxi, ChinaDepartment of Obstetrics and Gynecology, The First Clinical Medical College of Jinan University, Guangzhou, Guangdong, ChinaAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCenter of Reproductive Medicine, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaGuangxi Clinical Research Center for Obstetrics and Gynecology, Liuzhou, Guangxi, ChinaObstetrics and Gynecology Institute, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaCenter of Reproductive Medicine, Liuzhou Maternal and Child Health Hospital, Liuzhou, Guangxi, ChinaDepartment of Reproductive Medicine, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, ChinaCenter of Reproductive Medicine, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaGuangxi Clinical Research Center for Obstetrics and Gynecology, Liuzhou, Guangxi, ChinaObstetrics and Gynecology Institute, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaCenter of Reproductive Medicine, Liuzhou Maternal and Child Health Hospital, Liuzhou, Guangxi, ChinaCenter of Reproductive Medicine, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaGuangxi Clinical Research Center for Obstetrics and Gynecology, Liuzhou, Guangxi, ChinaObstetrics and Gynecology Institute, Guangzhou Women and Children’s Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, ChinaCenter of Reproductive Medicine, Liuzhou Maternal and Child Health Hospital, Liuzhou, Guangxi, ChinaBackgroundThis study investigates the potential impact of high progesterone (P) level on the day following human chorionic gonadotropin (HCG) injection on the clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET).MethodsRetrospective analysis was conducted on 6418 cycles of IVF-ET performed at Liuzhou Maternal and Child Health Hospital between August 2020 to December 2021. Excluding cycles with progesterone levels ≥1.5ng/ml on HCG injection, a total of 781 cycles were identified according to the standard, and they were divided into five groups according to the progesterone level on the day after HCG: Group A: progesterone level < 2.5 ng/ml (n = 128); Group B: 2.5 ng/ml ≤ progesterone level < 3.5 ng/ml (n = 174); Group C: 3.5 ng/ml ≤ progesterone level < 4.5 ng/ml (n = 153); Group D: 4.5 ng/ml ≤ progesterone level < 5.5 ng/ml (n = 132); Group E progesterone level ≥5.5 ng/ml(n=194). Comparative analyses of clinical data, including general clinical data, and clinical pregnancy outcomes such as clinical pregnancy rate, miscarriage rate, and live birth rate were performed among these groups.ResultsThere were significant differences in estradiol levels on HCG injection, but there were no differences in available embryo rate, clinical pregnancy rate, miscarriage rate, and live birth rate. Binary logistic regression analysis showed that there was no significant correlation between P level on the day after HCG injection and the live birth rate.ConclusionUnder the condition of low P level on HCG injection, high progesterone levels on the day after HCG injection does not affect the clinical pregnancy outcomes of IVF-ET.https://www.frontiersin.org/articles/10.3389/fendo.2024.1372753/fullprogesteroneendometrial receptivityin vitro fertilization-embryo transferclinical pregnancy outcomehuman chorionic gonadotropin injection progesterone |
| spellingShingle | Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Zhuo Liang Qiuyan Huang Qiuyan Huang Jiwei Huang Jiwei Huang Jiwei Huang Jiwei Huang Jinxiang Wu Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Dingyuan Zeng Pinxiu Huang Pinxiu Huang Pinxiu Huang Pinxiu Huang High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer Frontiers in Endocrinology progesterone endometrial receptivity in vitro fertilization-embryo transfer clinical pregnancy outcome human chorionic gonadotropin injection progesterone |
| title | High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer |
| title_full | High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer |
| title_fullStr | High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer |
| title_full_unstemmed | High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer |
| title_short | High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes in in vitro fertilization-embryo transfer |
| title_sort | high progesterone levels on the day after hcg injection has no effect on clinical pregnancy outcomes in in vitro fertilization embryo transfer |
| topic | progesterone endometrial receptivity in vitro fertilization-embryo transfer clinical pregnancy outcome human chorionic gonadotropin injection progesterone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1372753/full |
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