Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats
INTRODUCTION[|]The aim of this study was to investigate the protective effect of Urtica dioica (UD) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.[¤]METHODS[|]Total of 32 male Wistar albino rats were divided into 4 groups (8 animals per group) as follows: Group 1, sham-op...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-06-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-28482 |
| _version_ | 1797917865526951936 |
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| author | Hakan Akdere |
| author_facet | Hakan Akdere |
| author_sort | Hakan Akdere |
| collection | DOAJ |
| description | INTRODUCTION[|]The aim of this study was to investigate the protective effect of Urtica dioica (UD) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.[¤]METHODS[|]Total of 32 male Wistar albino rats were divided into 4 groups (8 animals per group) as follows: Group 1, sham-operated control group; Group 2, I/R group; Group 3, UD (250 mg/kg for 14 days) group; and Group 4, I/R+UD (250 mg/kg for 14 days) group. Testicular torsion was created by rotating the right testis 720º clockwise. Ischemia period was 5 hours and orchidectomy was performed after 5 hours of detorsion.[¤]RESULTS[|]Biochemical analyses of testicular tissue revealed malondialdehyde level was significantly higher in I/R group compared with that of control group and UD group (p<0.01). Significant increase was also observed in I/R+UD group when compared with control group and UD group (p<0.05). Testis tissue glutathione level was not significantly different between groups (p>0.05). Additionally, UD-treated animals had better histopathological findings compared with I/R group.[¤]DISCUSSION AND CONCLUSION[|]There are very few studies of histopathological changes in UD treatment of testicular torsion/detorsion-induced I/R injury in rats. UD may be a promising approach for treatment of testicular torsion.[¤] |
| first_indexed | 2024-04-10T13:20:11Z |
| format | Article |
| id | doaj.art-597ef820000c418c8b3102041f37e43e |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T13:20:11Z |
| publishDate | 2017-06-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-597ef820000c418c8b3102041f37e43e2023-02-15T16:12:04ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982017-06-012811710.14744/scie.2017.28482KEAH-28482Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in RatsHakan Akdere0Department of Urology, Trakya University Faculty of Medicine, Edirne, TurkeyINTRODUCTION[|]The aim of this study was to investigate the protective effect of Urtica dioica (UD) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.[¤]METHODS[|]Total of 32 male Wistar albino rats were divided into 4 groups (8 animals per group) as follows: Group 1, sham-operated control group; Group 2, I/R group; Group 3, UD (250 mg/kg for 14 days) group; and Group 4, I/R+UD (250 mg/kg for 14 days) group. Testicular torsion was created by rotating the right testis 720º clockwise. Ischemia period was 5 hours and orchidectomy was performed after 5 hours of detorsion.[¤]RESULTS[|]Biochemical analyses of testicular tissue revealed malondialdehyde level was significantly higher in I/R group compared with that of control group and UD group (p<0.01). Significant increase was also observed in I/R+UD group when compared with control group and UD group (p<0.05). Testis tissue glutathione level was not significantly different between groups (p>0.05). Additionally, UD-treated animals had better histopathological findings compared with I/R group.[¤]DISCUSSION AND CONCLUSION[|]There are very few studies of histopathological changes in UD treatment of testicular torsion/detorsion-induced I/R injury in rats. UD may be a promising approach for treatment of testicular torsion.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-28482ischemia-reperfusionurtica dioicaorchiectomytesticular torsion/detorsion |
| spellingShingle | Hakan Akdere Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats Southern Clinics of Istanbul Eurasia ischemia-reperfusion urtica dioica orchiectomy testicular torsion/detorsion |
| title | Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats |
| title_full | Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats |
| title_fullStr | Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats |
| title_full_unstemmed | Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats |
| title_short | Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats |
| title_sort | protective role of urtica dioica on testicular torsion detorsion induced ischemia reperfusion injury in rats |
| topic | ischemia-reperfusion urtica dioica orchiectomy testicular torsion/detorsion |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=KEAH-28482 |
| work_keys_str_mv | AT hakanakdere protectiveroleofurticadioicaontesticulartorsiondetorsioninducedischemiareperfusioninjuryinrats |