Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China.
Soluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN).We measured the plasma suPAR levels in 138 patients wit...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4575041?pdf=render |
| _version_ | 1818542922065248256 |
|---|---|
| author | Shui-Ming Guo Min Han Mei-Xue Chen Yong Ning Guang-Chang Pei Yue-Qiang Li Wei Dai Shu-Wang Ge Yuan-Jun Deng Yan-Yan Guo Xiao-Qing Li Hermann Haller Gang Xu Song Rong |
| author_facet | Shui-Ming Guo Min Han Mei-Xue Chen Yong Ning Guang-Chang Pei Yue-Qiang Li Wei Dai Shu-Wang Ge Yuan-Jun Deng Yan-Yan Guo Xiao-Qing Li Hermann Haller Gang Xu Song Rong |
| author_sort | Shui-Ming Guo |
| collection | DOAJ |
| description | Soluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN).We measured the plasma suPAR levels in 138 patients with IgAN, and then their clinical and pathological relationships were analyzed.We found that the plasma suPAR levels were significantly correlated with age and renal function by both univariate and multivariate analysis in our IgAN patient cohort. Female had higher plasma suPAR levels and no significant correlation was observed between plasma suPAR levels and 24-h urine protein and highly sensitive C-reaction protein with multivariate analysis. In our cohort, sixty of these IgAN patients could be diagnosed with a type of FSGS lesions. The plasma suPAR levels were higher in the IgAN patients with FSGS lesions than in the IgAN patients without FSGS lesions by univariate (P < 0.0001) and multivariate (P < 0.001) analysis adjusting for other predictor variables, which might be helpful to differentiate the pathological changes with and without FSGS lesions. And the optimal cutoff value was 1806 pg/ml in this study. The plasma suPAR concentrations were also associated with the degree of tubular atrophy/interstitial fibrosis in both univariate and multivariate analysis. In multivariate analysis, the plasma suPAR levels were correlated with the percentage of crescents, not global sclerosis and arterial lesions.Our study suggested that the plasma suPAR levels were associated with age, gender, renal function, the degree of tubular atrophy/interstitial fibrosis and the percentage of crescent formation. The plasma suPAR might be a potential predictor for the presence of FSGS pathological lesions in Chinese patients with IgAN. |
| first_indexed | 2024-12-11T22:28:31Z |
| format | Article |
| id | doaj.art-5980a40b73b84fee9df3d1ccb941114d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:28:31Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5980a40b73b84fee9df3d1ccb941114d2022-12-22T00:48:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013871810.1371/journal.pone.0138718Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China.Shui-Ming GuoMin HanMei-Xue ChenYong NingGuang-Chang PeiYue-Qiang LiWei DaiShu-Wang GeYuan-Jun DengYan-Yan GuoXiao-Qing LiHermann HallerGang XuSong RongSoluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN).We measured the plasma suPAR levels in 138 patients with IgAN, and then their clinical and pathological relationships were analyzed.We found that the plasma suPAR levels were significantly correlated with age and renal function by both univariate and multivariate analysis in our IgAN patient cohort. Female had higher plasma suPAR levels and no significant correlation was observed between plasma suPAR levels and 24-h urine protein and highly sensitive C-reaction protein with multivariate analysis. In our cohort, sixty of these IgAN patients could be diagnosed with a type of FSGS lesions. The plasma suPAR levels were higher in the IgAN patients with FSGS lesions than in the IgAN patients without FSGS lesions by univariate (P < 0.0001) and multivariate (P < 0.001) analysis adjusting for other predictor variables, which might be helpful to differentiate the pathological changes with and without FSGS lesions. And the optimal cutoff value was 1806 pg/ml in this study. The plasma suPAR concentrations were also associated with the degree of tubular atrophy/interstitial fibrosis in both univariate and multivariate analysis. In multivariate analysis, the plasma suPAR levels were correlated with the percentage of crescents, not global sclerosis and arterial lesions.Our study suggested that the plasma suPAR levels were associated with age, gender, renal function, the degree of tubular atrophy/interstitial fibrosis and the percentage of crescent formation. The plasma suPAR might be a potential predictor for the presence of FSGS pathological lesions in Chinese patients with IgAN.http://europepmc.org/articles/PMC4575041?pdf=render |
| spellingShingle | Shui-Ming Guo Min Han Mei-Xue Chen Yong Ning Guang-Chang Pei Yue-Qiang Li Wei Dai Shu-Wang Ge Yuan-Jun Deng Yan-Yan Guo Xiao-Qing Li Hermann Haller Gang Xu Song Rong Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. PLoS ONE |
| title | Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. |
| title_full | Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. |
| title_fullStr | Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. |
| title_full_unstemmed | Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. |
| title_short | Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China. |
| title_sort | soluble urokinase receptor levels are correlated with focal segmental glomerulosclerosis lesions in iga nephropathy a cohort study from china |
| url | http://europepmc.org/articles/PMC4575041?pdf=render |
| work_keys_str_mv | AT shuimingguo solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT minhan solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT meixuechen solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT yongning solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT guangchangpei solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT yueqiangli solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT weidai solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT shuwangge solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT yuanjundeng solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT yanyanguo solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT xiaoqingli solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT hermannhaller solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT gangxu solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina AT songrong solubleurokinasereceptorlevelsarecorrelatedwithfocalsegmentalglomerulosclerosislesionsiniganephropathyacohortstudyfromchina |