Leptomeningeal dissemination in pediatric brain tumors
Leptomeningeal disease (LMD) in pediatric brain tumors (PBTs) is a poorly understood and categorized phenomenon. LMD incidence rates, as well as diagnosis, treatment, and screening practices, vary greatly depending on the primary tumor pathology. While LMD is encountered most frequently in medullobl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558623000234 |
| _version_ | 1797851300061249536 |
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| author | Carolina Cocito Brice Martin Alexandra M. Giantini-Larsen Marcus Valcarce-Aspegren Mark M. Souweidane Luca Szalontay Nadia Dahmane Jeffrey P. Greenfield |
| author_facet | Carolina Cocito Brice Martin Alexandra M. Giantini-Larsen Marcus Valcarce-Aspegren Mark M. Souweidane Luca Szalontay Nadia Dahmane Jeffrey P. Greenfield |
| author_sort | Carolina Cocito |
| collection | DOAJ |
| description | Leptomeningeal disease (LMD) in pediatric brain tumors (PBTs) is a poorly understood and categorized phenomenon. LMD incidence rates, as well as diagnosis, treatment, and screening practices, vary greatly depending on the primary tumor pathology. While LMD is encountered most frequently in medulloblastoma, reports of LMD have been described across a wide variety of PBT pathologies. LMD may be diagnosed simultaneously with the primary tumor, at time of recurrence, or as primary LMD without a primary intraparenchymal lesion. Dissemination and seeding of the cerebrospinal fluid (CSF) involves a modified invasion-metastasis cascade and is often the result of direct deposition of tumor cells into the CSF. Cells develop select environmental advantages to survive the harsh, nutrient poor and turbulent environment of the CSF and leptomeninges. Improved understanding of the molecular mechanisms that underlie LMD, along with improved diagnostic and treatment approaches, will help the prognosis of children affected by primary brain tumors. |
| first_indexed | 2024-04-09T19:15:39Z |
| format | Article |
| id | doaj.art-59817ddb3a384cd39f768179621d564d |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-04-09T19:15:39Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-59817ddb3a384cd39f768179621d564d2023-04-06T06:10:33ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862023-05-0139100898Leptomeningeal dissemination in pediatric brain tumorsCarolina Cocito0Brice Martin1Alexandra M. Giantini-Larsen2Marcus Valcarce-Aspegren3Mark M. Souweidane4Luca Szalontay5Nadia Dahmane6Jeffrey P. Greenfield7Weill Cornell Medical College, Department of Neurological Surgery, New York, NY, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United States; Yale School of Medicine, New Haven, CT, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United StatesDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United StatesWeill Cornell Medical College, Department of Neurological Surgery, New York, NY, United States; Corresponding author: Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, United States.Leptomeningeal disease (LMD) in pediatric brain tumors (PBTs) is a poorly understood and categorized phenomenon. LMD incidence rates, as well as diagnosis, treatment, and screening practices, vary greatly depending on the primary tumor pathology. While LMD is encountered most frequently in medulloblastoma, reports of LMD have been described across a wide variety of PBT pathologies. LMD may be diagnosed simultaneously with the primary tumor, at time of recurrence, or as primary LMD without a primary intraparenchymal lesion. Dissemination and seeding of the cerebrospinal fluid (CSF) involves a modified invasion-metastasis cascade and is often the result of direct deposition of tumor cells into the CSF. Cells develop select environmental advantages to survive the harsh, nutrient poor and turbulent environment of the CSF and leptomeninges. Improved understanding of the molecular mechanisms that underlie LMD, along with improved diagnostic and treatment approaches, will help the prognosis of children affected by primary brain tumors.http://www.sciencedirect.com/science/article/pii/S1476558623000234Leptomeningeal disseminationPediatricsBrain tumorsMedulloblastoma |
| spellingShingle | Carolina Cocito Brice Martin Alexandra M. Giantini-Larsen Marcus Valcarce-Aspegren Mark M. Souweidane Luca Szalontay Nadia Dahmane Jeffrey P. Greenfield Leptomeningeal dissemination in pediatric brain tumors Neoplasia: An International Journal for Oncology Research Leptomeningeal dissemination Pediatrics Brain tumors Medulloblastoma |
| title | Leptomeningeal dissemination in pediatric brain tumors |
| title_full | Leptomeningeal dissemination in pediatric brain tumors |
| title_fullStr | Leptomeningeal dissemination in pediatric brain tumors |
| title_full_unstemmed | Leptomeningeal dissemination in pediatric brain tumors |
| title_short | Leptomeningeal dissemination in pediatric brain tumors |
| title_sort | leptomeningeal dissemination in pediatric brain tumors |
| topic | Leptomeningeal dissemination Pediatrics Brain tumors Medulloblastoma |
| url | http://www.sciencedirect.com/science/article/pii/S1476558623000234 |
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