Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53

Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53

Abstract Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, a cleavage peptide off fibronectin type III domain-containing 5, has been shown to preserve cardiac function in cardiac ischemia–r...

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Bibliographic Details
Main Authors: Yuan-juan Tang, Zhen Zhang, Tong Yan, Ken Chen, Guo-fan Xu, Shi-qiang Xiong, Dai-qian Wu, Jie Chen, Pedro A. Jose, Chun-yu Zeng, Jin-juan Fu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cardiovascular Diabetology
Subjects:
Type 1 diabetic cardiomyopathy
Ferroptosis
Irisin
p53
SIRT1
Online Access:https://doi.org/10.1186/s12933-024-02183-5

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