Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling

Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling

Protein arginine methyltransferase 1 (PRMT1) is the most predominant PRMT and is type I, meaning it generates monomethylarginine and asymmetric dimethylarginine. PRMT1 has functions in oxidative stress, inflammation and cancers, and modulates diverse diseases; consequently, numerous trials to develo...

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Bibliographic Details
Main Authors: Eunji Kim, Jiwon Jang, Jae Gwang Park, Kyung-Hee Kim, Keejung Yoon, Byong Chul Yoo, Jae Youl Cho
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
protein arginine methyltransferase 1 (PRMT1)
TC-E 5003
inflammation
AP-1
NF-κB
Online Access:https://www.mdpi.com/1422-0067/21/9/3058

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