Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target
Calcium plays a fundamental role in various signaling pathways and cellular processes in the human organism. In the nervous system, voltage-gated calcium channels such as L-type calcium channels (LTCCs) are critical elements in mediating neurotransmitter release, synaptic integration and plasticity....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037022005438 |
| _version_ | 1827577668138172416 |
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| author | Chelsea A. Crossley Vishaal Rajani Qi Yuan |
| author_facet | Chelsea A. Crossley Vishaal Rajani Qi Yuan |
| author_sort | Chelsea A. Crossley |
| collection | DOAJ |
| description | Calcium plays a fundamental role in various signaling pathways and cellular processes in the human organism. In the nervous system, voltage-gated calcium channels such as L-type calcium channels (LTCCs) are critical elements in mediating neurotransmitter release, synaptic integration and plasticity. Dysfunction of LTCCs has been implicated in both aging and Alzheimer’s Disease (AD), constituting a key component of calcium hypothesis of AD. As such, LTCCs are a promising drug target in AD. However, due to their structural and functional complexity, the mechanisms by which LTCCs contribute to AD are still unclear. In this review, we briefly summarize the structure, function, and modulation of LTCCs that are the backbone for understanding pathological processes involving LTCCs. We suggest targeting molecular pathways up-regulating LTCCs in AD may be a more promising approach, given the diverse physiological functions of LTCCs and the ineffectiveness of LTCC blockers in clinical studies. |
| first_indexed | 2024-03-08T21:31:10Z |
| format | Article |
| id | doaj.art-5984ac44bc61464398f12a188ea6b136 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:31:10Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-5984ac44bc61464398f12a188ea6b1362023-12-21T07:30:14ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-01211120Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic targetChelsea A. Crossley0Vishaal Rajani1Qi Yuan2Biomedical Sciences, Faculty of Medicine, Memorial University, CanadaBiomedical Sciences, Faculty of Medicine, Memorial University, CanadaCorresponding author at: Biomedical Sciences, Faculty of Medicine, Memorial University, St. John’s, NL A1B 3V6, Canada.; Biomedical Sciences, Faculty of Medicine, Memorial University, CanadaCalcium plays a fundamental role in various signaling pathways and cellular processes in the human organism. In the nervous system, voltage-gated calcium channels such as L-type calcium channels (LTCCs) are critical elements in mediating neurotransmitter release, synaptic integration and plasticity. Dysfunction of LTCCs has been implicated in both aging and Alzheimer’s Disease (AD), constituting a key component of calcium hypothesis of AD. As such, LTCCs are a promising drug target in AD. However, due to their structural and functional complexity, the mechanisms by which LTCCs contribute to AD are still unclear. In this review, we briefly summarize the structure, function, and modulation of LTCCs that are the backbone for understanding pathological processes involving LTCCs. We suggest targeting molecular pathways up-regulating LTCCs in AD may be a more promising approach, given the diverse physiological functions of LTCCs and the ineffectiveness of LTCC blockers in clinical studies.http://www.sciencedirect.com/science/article/pii/S2001037022005438L-type calcium channelAgingAlzheimer’s diseaseβ-AmyloidTau |
| spellingShingle | Chelsea A. Crossley Vishaal Rajani Qi Yuan Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target Computational and Structural Biotechnology Journal L-type calcium channel Aging Alzheimer’s disease β-Amyloid Tau |
| title | Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target |
| title_full | Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target |
| title_fullStr | Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target |
| title_full_unstemmed | Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target |
| title_short | Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target |
| title_sort | modulation of l type calcium channels in alzheimer s disease a potential therapeutic target |
| topic | L-type calcium channel Aging Alzheimer’s disease β-Amyloid Tau |
| url | http://www.sciencedirect.com/science/article/pii/S2001037022005438 |
| work_keys_str_mv | AT chelseaacrossley modulationofltypecalciumchannelsinalzheimersdiseaseapotentialtherapeutictarget AT vishaalrajani modulationofltypecalciumchannelsinalzheimersdiseaseapotentialtherapeutictarget AT qiyuan modulationofltypecalciumchannelsinalzheimersdiseaseapotentialtherapeutictarget |