DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Abstract Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC function has been mostly assessed using transplan...

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Bibliographic Details
Main Authors: Jos Urbanus, Jason Cosgrove, Joost B. Beltman, Yuval Elhanati, Rafael A. Moral, Cecile Conrad, Jeroen W. van Heijst, Emilie Tubeuf, Arno Velds, Lianne Kok, Candice Merle, Jens P. Magnusson, Léa Guyonnet, Jonas Frisén, Silvia Fre, Aleksandra M. Walczak, Thierry Mora, Heinz Jacobs, Ton N. Schumacher, Leïla Perié
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37167-8

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