Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness
Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effec...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/1/16 |
| _version_ | 1797446891361796096 |
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| author | Tomas Venckunas Marius Brazaitis Audrius Snieckus Mantas Mickevicius Nerijus Eimantas Andrejus Subocius Dalia Mickeviciene Håkan Westerblad Sigitas Kamandulis |
| author_facet | Tomas Venckunas Marius Brazaitis Audrius Snieckus Mantas Mickevicius Nerijus Eimantas Andrejus Subocius Dalia Mickeviciene Håkan Westerblad Sigitas Kamandulis |
| author_sort | Tomas Venckunas |
| collection | DOAJ |
| description | Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effects in pathological conditions with chronically increased ROS. Here, young male volunteers were exposed to 3 weeks of unloading of the dominant leg followed by 3 weeks of resistance training without (Ctrl group) or with the addition of all-out cycling HIIT. Changes in muscle thickness were assessed by ultrasonography, and contractile function was studied by measuring the torque during maximal voluntary contractions (MVC). The results show an ~6% decrease in vastus lateralis thickness after the unloading period, which was fully restored after the subsequent training period in both the Ctrl and HIIT groups. MVC torque was decreased by ~11% after the unloading period and recovered fully during the subsequent training period in both groups. All-out cycling performance was improved by the 3 weeks of HIIT. In conclusion, the decline in muscle size and function after 3 weeks of unloading was restored by 3 weeks of resistance training regardless of whether it was combined with HIIT. |
| first_indexed | 2024-03-09T13:47:07Z |
| format | Article |
| id | doaj.art-598d01bf77ca44dbac6c14d3671855f1 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:47:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-598d01bf77ca44dbac6c14d3671855f12023-11-30T20:57:09ZengMDPI AGAntioxidants2076-39212022-12-011211610.3390/antiox12010016Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle WeaknessTomas Venckunas0Marius Brazaitis1Audrius Snieckus2Mantas Mickevicius3Nerijus Eimantas4Andrejus Subocius5Dalia Mickeviciene6Håkan Westerblad7Sigitas Kamandulis8Institute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, SwedenInstitute of Sports Science and Innovations, Lithuanian Sports University, 44221 Kaunas, LithuaniaInactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves bursts of high ROS production, can have positive effects in pathological conditions with chronically increased ROS. Here, young male volunteers were exposed to 3 weeks of unloading of the dominant leg followed by 3 weeks of resistance training without (Ctrl group) or with the addition of all-out cycling HIIT. Changes in muscle thickness were assessed by ultrasonography, and contractile function was studied by measuring the torque during maximal voluntary contractions (MVC). The results show an ~6% decrease in vastus lateralis thickness after the unloading period, which was fully restored after the subsequent training period in both the Ctrl and HIIT groups. MVC torque was decreased by ~11% after the unloading period and recovered fully during the subsequent training period in both groups. All-out cycling performance was improved by the 3 weeks of HIIT. In conclusion, the decline in muscle size and function after 3 weeks of unloading was restored by 3 weeks of resistance training regardless of whether it was combined with HIIT.https://www.mdpi.com/2076-3921/12/1/16inactivitymuscle weaknessmuscle thicknesslow-frequency force depressionresistance traininghigh-intensity interval training |
| spellingShingle | Tomas Venckunas Marius Brazaitis Audrius Snieckus Mantas Mickevicius Nerijus Eimantas Andrejus Subocius Dalia Mickeviciene Håkan Westerblad Sigitas Kamandulis Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness Antioxidants inactivity muscle weakness muscle thickness low-frequency force depression resistance training high-intensity interval training |
| title | Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness |
| title_full | Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness |
| title_fullStr | Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness |
| title_full_unstemmed | Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness |
| title_short | Adding High-Intensity Interval Training to Classical Resistance Training Does Not Impede the Recovery from Inactivity-Induced Leg Muscle Weakness |
| title_sort | adding high intensity interval training to classical resistance training does not impede the recovery from inactivity induced leg muscle weakness |
| topic | inactivity muscle weakness muscle thickness low-frequency force depression resistance training high-intensity interval training |
| url | https://www.mdpi.com/2076-3921/12/1/16 |
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