Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats
Abstract.: The neuropeptide galanin has a role in promoting alcohol consumption and general feeding behavior. The galanin-3 receptor (GALR3) subtype is implicated in modulating the consumption of alcohol and has therefore been identified as a potential target for new pharmacotherapies to treat alcoh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319301446 |
| _version_ | 1818985747666960384 |
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| author | Belinda L. Ash Tim Quach Spencer J. Williams Andrew J. Lawrence Elvan Djouma |
| author_facet | Belinda L. Ash Tim Quach Spencer J. Williams Andrew J. Lawrence Elvan Djouma |
| author_sort | Belinda L. Ash |
| collection | DOAJ |
| description | Abstract.: The neuropeptide galanin has a role in promoting alcohol consumption and general feeding behavior. The galanin-3 receptor (GALR3) subtype is implicated in modulating the consumption of alcohol and has therefore been identified as a potential target for new pharmacotherapies to treat alcohol use disorders. We have previously shown that the selective GALR3 antagonist SNAP 37889 reduced voluntary alcohol consumption in iP (alcohol-preferring) rats. The present study firstly aimed to investigate the effect of GALR3 antagonism on the motivational properties of alcohol. Secondly, the potential of GALR3 as a therapeutic target in the prevention of relapse was investigated in response to alcohol-conditioned cues. Administration of SNAP 37889 (30 mg/kg, i.p.) significantly reduced the breakpoint for ethanol under a progressive-ratio operant responding schedule of reinforcement. SNAP 37889 also significantly reduced reinstatement of alcohol-seeking in response to re-exposure to conditioned cues that were previously associated with the availability of alcohol. Collectively, results from the current study provide new evidence of GALR3 involvement in cue-induced relapse and provide further evidence that GALR3 antagonism reduces the motivational drive to consume alcohol. These findings validate further research in to the potential use of SNAP 37889 and other GALR3 antagonists to treat alcohol abuse disorders in humans. Keywords:: alcohol, galanin, galanin-3 receptor (GALR3), operant self-administration, cue-induced reinstatement |
| first_indexed | 2024-12-20T18:39:49Z |
| format | Article |
| id | doaj.art-598e0d6ac0634b24a957507b76b6a6b8 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-20T18:39:49Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-598e0d6ac0634b24a957507b76b6a6b82022-12-21T19:29:49ZengElsevierJournal of Pharmacological Sciences1347-86132014-01-011252211216Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP RatsBelinda L. Ash0Tim Quach1Spencer J. Williams2Andrew J. Lawrence3Elvan Djouma4Department of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora, Victoria 3086, AustraliaBio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, AustraliaBio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, AustraliaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia; Melbourne Brain Centre, University of Melbourne, Parkville, Victoria 3010, AustraliaDepartment of Human Biosciences, Faculty of Health Sciences, La Trobe University, Bundoora, Victoria 3086, Australia; Corresponding author. e.djouma@latrobe.edu.auAbstract.: The neuropeptide galanin has a role in promoting alcohol consumption and general feeding behavior. The galanin-3 receptor (GALR3) subtype is implicated in modulating the consumption of alcohol and has therefore been identified as a potential target for new pharmacotherapies to treat alcohol use disorders. We have previously shown that the selective GALR3 antagonist SNAP 37889 reduced voluntary alcohol consumption in iP (alcohol-preferring) rats. The present study firstly aimed to investigate the effect of GALR3 antagonism on the motivational properties of alcohol. Secondly, the potential of GALR3 as a therapeutic target in the prevention of relapse was investigated in response to alcohol-conditioned cues. Administration of SNAP 37889 (30 mg/kg, i.p.) significantly reduced the breakpoint for ethanol under a progressive-ratio operant responding schedule of reinforcement. SNAP 37889 also significantly reduced reinstatement of alcohol-seeking in response to re-exposure to conditioned cues that were previously associated with the availability of alcohol. Collectively, results from the current study provide new evidence of GALR3 involvement in cue-induced relapse and provide further evidence that GALR3 antagonism reduces the motivational drive to consume alcohol. These findings validate further research in to the potential use of SNAP 37889 and other GALR3 antagonists to treat alcohol abuse disorders in humans. Keywords:: alcohol, galanin, galanin-3 receptor (GALR3), operant self-administration, cue-induced reinstatementhttp://www.sciencedirect.com/science/article/pii/S1347861319301446 |
| spellingShingle | Belinda L. Ash Tim Quach Spencer J. Williams Andrew J. Lawrence Elvan Djouma Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats Journal of Pharmacological Sciences |
| title | Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats |
| title_full | Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats |
| title_fullStr | Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats |
| title_full_unstemmed | Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats |
| title_short | Galanin-3 Receptor Antagonism by SNAP 37889 Reduces Motivation to Self-administer Alcohol and Attenuates Cue-Induced Reinstatement of Alcohol-Seeking in iP Rats |
| title_sort | galanin 3 receptor antagonism by snap 37889 reduces motivation to self administer alcohol and attenuates cue induced reinstatement of alcohol seeking in ip rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319301446 |
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