The Mysteries around the BCL-2 Family Member BOK
BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/12/1638 |
| _version_ | 1827700753257463808 |
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| author | Raed Shalaby Hector Flores-Romero Ana J. García-Sáez |
| author_facet | Raed Shalaby Hector Flores-Romero Ana J. García-Sáez |
| author_sort | Raed Shalaby |
| collection | DOAJ |
| description | BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate, BOK has been associated with a plethora of non-apoptotic functions that makes this protein unpredictable when dictating cell fate. Here, we compile the current knowledge and open questions about this paradoxical protein with a special focus on its structural features as the key aspect to understand BOK biological functions. |
| first_indexed | 2024-03-10T14:18:23Z |
| format | Article |
| id | doaj.art-5990886cfb3344f3a79408aedf66ddaa |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T14:18:23Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5990886cfb3344f3a79408aedf66ddaa2023-11-20T23:34:33ZengMDPI AGBiomolecules2218-273X2020-12-011012163810.3390/biom10121638The Mysteries around the BCL-2 Family Member BOKRaed Shalaby0Hector Flores-Romero1Ana J. García-Sáez2Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, GermanyInstitute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, GermanyInstitute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, GermanyBOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate, BOK has been associated with a plethora of non-apoptotic functions that makes this protein unpredictable when dictating cell fate. Here, we compile the current knowledge and open questions about this paradoxical protein with a special focus on its structural features as the key aspect to understand BOK biological functions.https://www.mdpi.com/2218-273X/10/12/1638BOKMOMPBCL-2 familyapoptosis |
| spellingShingle | Raed Shalaby Hector Flores-Romero Ana J. García-Sáez The Mysteries around the BCL-2 Family Member BOK Biomolecules BOK MOMP BCL-2 family apoptosis |
| title | The Mysteries around the BCL-2 Family Member BOK |
| title_full | The Mysteries around the BCL-2 Family Member BOK |
| title_fullStr | The Mysteries around the BCL-2 Family Member BOK |
| title_full_unstemmed | The Mysteries around the BCL-2 Family Member BOK |
| title_short | The Mysteries around the BCL-2 Family Member BOK |
| title_sort | mysteries around the bcl 2 family member bok |
| topic | BOK MOMP BCL-2 family apoptosis |
| url | https://www.mdpi.com/2218-273X/10/12/1638 |
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