Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model
Emerging computational tools such as healthcare digital twin modeling are enabling the creation of patient-specific surgical planning, including microwave ablation to treat primary and secondary liver cancers. Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed...
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| Format: | Article |
| Language: | English |
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10375319/ |
| _version_ | 1797272685022019584 |
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| author | Frankangel Servin Jarrod A. Collins Jon S. Heiselman Katherine C. Frederick-Dyer Virginia B. Planz Sunil K. Geevarghese Daniel B. Brown William R. Jarnagin Michael I. Miga |
| author_facet | Frankangel Servin Jarrod A. Collins Jon S. Heiselman Katherine C. Frederick-Dyer Virginia B. Planz Sunil K. Geevarghese Daniel B. Brown William R. Jarnagin Michael I. Miga |
| author_sort | Frankangel Servin |
| collection | DOAJ |
| description | Emerging computational tools such as healthcare digital twin modeling are enabling the creation of patient-specific surgical planning, including microwave ablation to treat primary and secondary liver cancers. Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. In microwave ablation (MWA), tissue-specific factors including tissue perfusion, hepatic steatosis, and fibrosis affect therapeutic extent, but current thermal dosing guidelines do not account for these parameters. This study establishes an MR imaging framework to construct three-dimensional biophysical digital twins to predict ablation delivery in livers with 5 levels of fat content in the presence of a tumor. Four microwave antenna placement strategies were considered, and simulated microwave ablations were then performed using 915 MHz and 2450 MHz antennae in <italic>Tumor Naïve DTs</italic> (control), and <italic>Tumor Informed DTs</italic> at five grades of steatosis. Across the range of fatty liver steatosis grades, fat content was found to significantly increase ablation volumes by approximately 29–l42% in the Tumor Naïve and 55–60% in the <italic>Tumor Informed DTs</italic> in 915 MHz and 2450 MHz antenna simulations. The presence of tumor did not significantly affect ablation volumes within the same steatosis grade in 915 MHz simulations, but did significantly increase ablation volumes within mild-, moderate-, and high-fat steatosis grades in 2450 MHz simulations. An analysis of signed distance to agreement for placement strategies suggests that accounting for patient-specific tumor tissue properties significantly impacts ablation forecasting for the preoperative evaluation of ablation zone coverage. |
| first_indexed | 2024-03-07T14:31:56Z |
| format | Article |
| id | doaj.art-599109960a4041f59d329af21a1b20a4 |
| institution | Directory Open Access Journal |
| issn | 2644-1276 |
| language | English |
| last_indexed | 2024-03-07T14:31:56Z |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj.art-599109960a4041f59d329af21a1b20a42024-03-06T00:01:45ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01510712410.1109/OJEMB.2023.334573310375319Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational ModelFrankangel Servin0https://orcid.org/0009-0008-8511-0052Jarrod A. Collins1https://orcid.org/0000-0003-4388-1779Jon S. Heiselman2https://orcid.org/0000-0002-4414-8846Katherine C. Frederick-Dyer3https://orcid.org/0000-0002-3281-1452Virginia B. Planz4https://orcid.org/0000-0002-8365-2324Sunil K. Geevarghese5https://orcid.org/0000-0001-6356-0310Daniel B. Brown6William R. Jarnagin7https://orcid.org/0000-0002-1635-5768Michael I. Miga8https://orcid.org/0000-0002-0694-9765Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USADepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USAEmerging computational tools such as healthcare digital twin modeling are enabling the creation of patient-specific surgical planning, including microwave ablation to treat primary and secondary liver cancers. Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. In microwave ablation (MWA), tissue-specific factors including tissue perfusion, hepatic steatosis, and fibrosis affect therapeutic extent, but current thermal dosing guidelines do not account for these parameters. This study establishes an MR imaging framework to construct three-dimensional biophysical digital twins to predict ablation delivery in livers with 5 levels of fat content in the presence of a tumor. Four microwave antenna placement strategies were considered, and simulated microwave ablations were then performed using 915 MHz and 2450 MHz antennae in <italic>Tumor Naïve DTs</italic> (control), and <italic>Tumor Informed DTs</italic> at five grades of steatosis. Across the range of fatty liver steatosis grades, fat content was found to significantly increase ablation volumes by approximately 29–l42% in the Tumor Naïve and 55–60% in the <italic>Tumor Informed DTs</italic> in 915 MHz and 2450 MHz antenna simulations. The presence of tumor did not significantly affect ablation volumes within the same steatosis grade in 915 MHz simulations, but did significantly increase ablation volumes within mild-, moderate-, and high-fat steatosis grades in 2450 MHz simulations. An analysis of signed distance to agreement for placement strategies suggests that accounting for patient-specific tumor tissue properties significantly impacts ablation forecasting for the preoperative evaluation of ablation zone coverage.https://ieeexplore.ieee.org/document/10375319/Computational modeldigital twinfatty liver diseasefinite elementliver cancermicrowave ablation |
| spellingShingle | Frankangel Servin Jarrod A. Collins Jon S. Heiselman Katherine C. Frederick-Dyer Virginia B. Planz Sunil K. Geevarghese Daniel B. Brown William R. Jarnagin Michael I. Miga Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model IEEE Open Journal of Engineering in Medicine and Biology Computational model digital twin fatty liver disease finite element liver cancer microwave ablation |
| title | Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model |
| title_full | Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model |
| title_fullStr | Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model |
| title_full_unstemmed | Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model |
| title_short | Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model |
| title_sort | simulation of image guided microwave ablation therapy using a digital twin computational model |
| topic | Computational model digital twin fatty liver disease finite element liver cancer microwave ablation |
| url | https://ieeexplore.ieee.org/document/10375319/ |
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