Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial

Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial

Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress and systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been sho...

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Bibliographic Details
Main Authors: Izabella P. Safe, Eduardo P. Amaral, Mariana Araújo-Pereira, Marcus V. G. Lacerda, Vitoria S. Printes, Alexandra B. Souza, Francisco Beraldi-Magalhães, Wuelton M. Monteiro, Vanderson S. Sampaio, Beatriz Barreto-Duarte, Alice M. S. Andrade, Renata Spener-Gomes, Allyson Guimarães Costa, Marcelo Cordeiro-Santos, Bruno B. Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
oxidative stress
N-acetylcysteine treatment
glutathione
RIPENACTB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.602589/full

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