Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis
Abstract Objective The gold standard for a soft tissue augmentation around implants is a subepithelial connective tissue graft (CTG), but the xenogeneic collagen matrices (XCM) started to be used as an alternative. This systematic review aimed to assess the effectiveness XCM in comparison to CTG for...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-023-03475-0 |
| _version_ | 1797451266518941696 |
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| author | Igor Ashurko Svetlana Tarasenko Mary Magdalyanova Svetlana Bokareva Maxim Balyasin Anna Galyas Marina Khamidova Mariia Zhornik Alexey Unkovskiy |
| author_facet | Igor Ashurko Svetlana Tarasenko Mary Magdalyanova Svetlana Bokareva Maxim Balyasin Anna Galyas Marina Khamidova Mariia Zhornik Alexey Unkovskiy |
| author_sort | Igor Ashurko |
| collection | DOAJ |
| description | Abstract Objective The gold standard for a soft tissue augmentation around implants is a subepithelial connective tissue graft (CTG), but the xenogeneic collagen matrices (XCM) started to be used as an alternative. This systematic review aimed to assess the effectiveness XCM in comparison to CTG for the increasing the thickness of the soft tissue around implants. Data All studies included at least two parallel groups comparing the use of CTG and XCM with a minimum follow-up of 3 months. As the primary outcome, the amount of soft tissue thickness gain after soft tissue augmentation with XCM or CTG was assessed. Secondary outcomes were clinical and patient-related outcomes; evaluation of aesthetic outcomes, patient-reported outcomes measures (PROMs) and complications. Eligible studies were selected based on the inclusion criteria. Meta-analysis was applied whenever possible. The quality of the evidence of studies including in meta-analysis was assessed using the GRADE approach. Source A systematic literature search up to January 2022 was conducted using the following electronic databases: PubMed (MEDLINE), Scopus, Cochrane Library, LILACS, eLIBRARY.RU. Unpublished researches, the gray literature, nonprofit reports, government studies and other materials were reviewed electronically using an EASY search. An additional manual search was carried out in November 2022. Study selection Of the 1376 articles from the initial search, 8 randomized controlled trials (RCTs) (306 patients and 325 implants) were included in this systematic review, and 7 studies were part of the meta-analysis. Meta-analysis revealed that XCM is less effective than the CTG in increasing soft tissue thickness around dental implants. However, XCM also provides soft tissue thickness gain and can be recommended for use in various clinical situations. Clinical significance Previous systematic reviews and meta-analyses have shown that autologous grafts are more effective than collagen matrices in increasing soft tissue thickness, however, the latter can be used as an alternative. Studies included in previous systematic reviews varied in design, which could lead to limitations. The present systematic review and meta-analysis includes for the first time only randomized controlled clinical trials with collagen matrix of xenogeneic origin in the test group. Tight eligibility criteria were established, and the main parameter studied was soft tissue thickness. It was found that xenogeneic collagen matrix is effective for increasing soft tissue thickness around dental implants, however, the results obtained using an autogenous connective tissue graft are superior. |
| first_indexed | 2024-03-09T14:51:15Z |
| format | Article |
| id | doaj.art-5991ff59fc5d4f239778e727104b5376 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-09T14:51:15Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-5991ff59fc5d4f239778e727104b53762023-11-26T14:25:30ZengBMCBMC Oral Health1472-68312023-10-0123113410.1186/s12903-023-03475-0Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysisIgor Ashurko0Svetlana Tarasenko1Mary Magdalyanova2Svetlana Bokareva3Maxim Balyasin4Anna Galyas5Marina Khamidova6Mariia Zhornik7Alexey Unkovskiy8Department of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityPeoples’ Friendship UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityDepartment of Dental Surgery, Sechenov First Moscow State Medical UniversityAbstract Objective The gold standard for a soft tissue augmentation around implants is a subepithelial connective tissue graft (CTG), but the xenogeneic collagen matrices (XCM) started to be used as an alternative. This systematic review aimed to assess the effectiveness XCM in comparison to CTG for the increasing the thickness of the soft tissue around implants. Data All studies included at least two parallel groups comparing the use of CTG and XCM with a minimum follow-up of 3 months. As the primary outcome, the amount of soft tissue thickness gain after soft tissue augmentation with XCM or CTG was assessed. Secondary outcomes were clinical and patient-related outcomes; evaluation of aesthetic outcomes, patient-reported outcomes measures (PROMs) and complications. Eligible studies were selected based on the inclusion criteria. Meta-analysis was applied whenever possible. The quality of the evidence of studies including in meta-analysis was assessed using the GRADE approach. Source A systematic literature search up to January 2022 was conducted using the following electronic databases: PubMed (MEDLINE), Scopus, Cochrane Library, LILACS, eLIBRARY.RU. Unpublished researches, the gray literature, nonprofit reports, government studies and other materials were reviewed electronically using an EASY search. An additional manual search was carried out in November 2022. Study selection Of the 1376 articles from the initial search, 8 randomized controlled trials (RCTs) (306 patients and 325 implants) were included in this systematic review, and 7 studies were part of the meta-analysis. Meta-analysis revealed that XCM is less effective than the CTG in increasing soft tissue thickness around dental implants. However, XCM also provides soft tissue thickness gain and can be recommended for use in various clinical situations. Clinical significance Previous systematic reviews and meta-analyses have shown that autologous grafts are more effective than collagen matrices in increasing soft tissue thickness, however, the latter can be used as an alternative. Studies included in previous systematic reviews varied in design, which could lead to limitations. The present systematic review and meta-analysis includes for the first time only randomized controlled clinical trials with collagen matrix of xenogeneic origin in the test group. Tight eligibility criteria were established, and the main parameter studied was soft tissue thickness. It was found that xenogeneic collagen matrix is effective for increasing soft tissue thickness around dental implants, however, the results obtained using an autogenous connective tissue graft are superior.https://doi.org/10.1186/s12903-023-03475-0Dental implantConnective tissue graftSubepithelial connective tissue graftSoft tissueCollagen matrixSoft tissue augmentation |
| spellingShingle | Igor Ashurko Svetlana Tarasenko Mary Magdalyanova Svetlana Bokareva Maxim Balyasin Anna Galyas Marina Khamidova Mariia Zhornik Alexey Unkovskiy Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis BMC Oral Health Dental implant Connective tissue graft Subepithelial connective tissue graft Soft tissue Collagen matrix Soft tissue augmentation |
| title | Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis |
| title_full | Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis |
| title_fullStr | Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis |
| title_full_unstemmed | Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis |
| title_short | Comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants: a systematic review and meta-analysis |
| title_sort | comparative analysis of xenogeneic collagen matrix and autogenous subepithelial connective tissue graft to increase soft tissue volume around dental implants a systematic review and meta analysis |
| topic | Dental implant Connective tissue graft Subepithelial connective tissue graft Soft tissue Collagen matrix Soft tissue augmentation |
| url | https://doi.org/10.1186/s12903-023-03475-0 |
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