Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions
This study evaluates the long-term effects of selective retina therapy (SRT) on the retinal pigment epithelium (RPE) and neuroretina in patients with central serous chorioretinopathy. SRT was performed on 36 patients using a Nd:YLF-Laser at 527 nm (R:GEN<sup>®</sup>, Lutronic, Goyang-Si,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/886 |
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| author | Maximilian Binter Migle Lindziute Christopher Rosenstein Carsten Framme Jan Tode |
| author_facet | Maximilian Binter Migle Lindziute Christopher Rosenstein Carsten Framme Jan Tode |
| author_sort | Maximilian Binter |
| collection | DOAJ |
| description | This study evaluates the long-term effects of selective retina therapy (SRT) on the retinal pigment epithelium (RPE) and neuroretina in patients with central serous chorioretinopathy. SRT was performed on 36 patients using a Nd:YLF-Laser at 527 nm (R:GEN<sup>®</sup>, Lutronic, Goyang-Si, Republic of Korea). A total of 994 titration spots were examined using up to three years’ multimodal imaging. Leakage in fluorescein angiography (FA) was observed after SRT in 523 lesions and resolved after one month. SRT lesions were not visible clinically, but appeared as brightly reflective areas in infrared and multicolor images. Normal morphology was observed in optical coherence tomography (OCT) immediately after SRT. After one month, thickening of the RPE and interdigitation zone changes were seen and disappeared after 539 ± 308 days. No RPE atrophies occurred during the observation period. Decreased fundus autofluorescence (FAF) was mostly observed directly after SRT followed by increased FAF at one month, which faded over time. A significant decrease in the number of visible lesions in the FA and FAF was observed within the three-year follow-up. OCT findings are consistent with animal studies showing SRT-related defect closure by hypertrophy and migration of neighboring cells without RPE atrophy or photoreceptor damage. This suggests that SRT is a safe treatment option for macular diseases and does not lead to retinal atrophy. |
| first_indexed | 2024-03-11T04:49:57Z |
| format | Article |
| id | doaj.art-599242761d144b5480417e1270df89c9 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T04:49:57Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-599242761d144b5480417e1270df89c92023-11-17T20:04:59ZengMDPI AGLife2075-17292023-03-0113488610.3390/life13040886Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser LesionsMaximilian Binter0Migle Lindziute1Christopher Rosenstein2Carsten Framme3Jan Tode4Department of Ophthalmology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Ophthalmology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Ophthalmology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Ophthalmology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Ophthalmology, Hannover Medical School, 30625 Hannover, GermanyThis study evaluates the long-term effects of selective retina therapy (SRT) on the retinal pigment epithelium (RPE) and neuroretina in patients with central serous chorioretinopathy. SRT was performed on 36 patients using a Nd:YLF-Laser at 527 nm (R:GEN<sup>®</sup>, Lutronic, Goyang-Si, Republic of Korea). A total of 994 titration spots were examined using up to three years’ multimodal imaging. Leakage in fluorescein angiography (FA) was observed after SRT in 523 lesions and resolved after one month. SRT lesions were not visible clinically, but appeared as brightly reflective areas in infrared and multicolor images. Normal morphology was observed in optical coherence tomography (OCT) immediately after SRT. After one month, thickening of the RPE and interdigitation zone changes were seen and disappeared after 539 ± 308 days. No RPE atrophies occurred during the observation period. Decreased fundus autofluorescence (FAF) was mostly observed directly after SRT followed by increased FAF at one month, which faded over time. A significant decrease in the number of visible lesions in the FA and FAF was observed within the three-year follow-up. OCT findings are consistent with animal studies showing SRT-related defect closure by hypertrophy and migration of neighboring cells without RPE atrophy or photoreceptor damage. This suggests that SRT is a safe treatment option for macular diseases and does not lead to retinal atrophy.https://www.mdpi.com/2075-1729/13/4/886selective retina treatmentcentral serous chorioretinopathymicropulse lasersubretinal fluidfluorescein angiographyOCT |
| spellingShingle | Maximilian Binter Migle Lindziute Christopher Rosenstein Carsten Framme Jan Tode Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions Life selective retina treatment central serous chorioretinopathy micropulse laser subretinal fluid fluorescein angiography OCT |
| title | Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions |
| title_full | Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions |
| title_fullStr | Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions |
| title_full_unstemmed | Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions |
| title_short | Long-Term Multimodal Imaging Analysis of Selective Retina Therapy Laser Lesions |
| title_sort | long term multimodal imaging analysis of selective retina therapy laser lesions |
| topic | selective retina treatment central serous chorioretinopathy micropulse laser subretinal fluid fluorescein angiography OCT |
| url | https://www.mdpi.com/2075-1729/13/4/886 |
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