The Underestimated Role of Platelets in Severe Infection a Narrative Review
Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity. Recently, some studies elucidated that the respons...
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/424 |
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| author | Alberto Fogagnolo Gianluca Calogero Campo Matilde Mari Graziella Pompei Rita Pavasini Carlo Alberto Volta Savino Spadaro |
| author_facet | Alberto Fogagnolo Gianluca Calogero Campo Matilde Mari Graziella Pompei Rita Pavasini Carlo Alberto Volta Savino Spadaro |
| author_sort | Alberto Fogagnolo |
| collection | DOAJ |
| description | Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity. Recently, some studies elucidated that the response of platelets to infections goes beyond a simple fall in platelets count; indeed, sepsis-induced thrombocytopenia can be associated with—or even anticipated by—several changes, including an altered morphological pattern, receptor expression and aggregation. Of note, alterations in platelet function and morphology can occur even with a normal platelet count and can modify, depending on the nature of the pathogen, the pattern of host response and the severity of the infection. The purpose of this review is to give an overview on the pathophysiological interaction between platelets and pathogens, as well as the clinical consequences of platelet dysregulation. Furthermore, we try to clarify how understanding the nature of platelet dysregulation may help to optimize the therapeutic approach. |
| first_indexed | 2024-03-10T00:04:14Z |
| format | Article |
| id | doaj.art-5993fec6fc6e456c8cc7f71a65be1b29 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:04:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5993fec6fc6e456c8cc7f71a65be1b292023-11-23T16:11:39ZengMDPI AGCells2073-44092022-01-0111342410.3390/cells11030424The Underestimated Role of Platelets in Severe Infection a Narrative ReviewAlberto Fogagnolo0Gianluca Calogero Campo1Matilde Mari2Graziella Pompei3Rita Pavasini4Carlo Alberto Volta5Savino Spadaro6Intensive Care Unit, Department of Translational Medicine and for Romagna, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, 44121 Ferrara, ItalyCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, ItalyIntensive Care Unit, Department of Translational Medicine and for Romagna, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, 44121 Ferrara, ItalyCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, ItalyCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, ItalyIntensive Care Unit, Department of Translational Medicine and for Romagna, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, 44121 Ferrara, ItalyIntensive Care Unit, Department of Translational Medicine and for Romagna, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, 44121 Ferrara, ItalyBeyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity. Recently, some studies elucidated that the response of platelets to infections goes beyond a simple fall in platelets count; indeed, sepsis-induced thrombocytopenia can be associated with—or even anticipated by—several changes, including an altered morphological pattern, receptor expression and aggregation. Of note, alterations in platelet function and morphology can occur even with a normal platelet count and can modify, depending on the nature of the pathogen, the pattern of host response and the severity of the infection. The purpose of this review is to give an overview on the pathophysiological interaction between platelets and pathogens, as well as the clinical consequences of platelet dysregulation. Furthermore, we try to clarify how understanding the nature of platelet dysregulation may help to optimize the therapeutic approach.https://www.mdpi.com/2073-4409/11/3/424plateletplatelet activationinfectioncritical care |
| spellingShingle | Alberto Fogagnolo Gianluca Calogero Campo Matilde Mari Graziella Pompei Rita Pavasini Carlo Alberto Volta Savino Spadaro The Underestimated Role of Platelets in Severe Infection a Narrative Review Cells platelet platelet activation infection critical care |
| title | The Underestimated Role of Platelets in Severe Infection a Narrative Review |
| title_full | The Underestimated Role of Platelets in Severe Infection a Narrative Review |
| title_fullStr | The Underestimated Role of Platelets in Severe Infection a Narrative Review |
| title_full_unstemmed | The Underestimated Role of Platelets in Severe Infection a Narrative Review |
| title_short | The Underestimated Role of Platelets in Severe Infection a Narrative Review |
| title_sort | underestimated role of platelets in severe infection a narrative review |
| topic | platelet platelet activation infection critical care |
| url | https://www.mdpi.com/2073-4409/11/3/424 |
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