Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain)
<i>Strongyloides stercoralis</i> infection is generally asymptomatic or mildly symptomatic, but in the immunosuppressed host, it is associated with more severe and complicated forms with a worse prognosis. <i>S. stercoralis</i> seroprevalence was studied in 256 patients befor...
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MDPI AG
2023-03-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/3/181 |
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| author | Cristina Carranza-Rodríguez Laura López-Delgado Álvaro Granados-Magan José-Luis Pérez-Arellano |
| author_facet | Cristina Carranza-Rodríguez Laura López-Delgado Álvaro Granados-Magan José-Luis Pérez-Arellano |
| author_sort | Cristina Carranza-Rodríguez |
| collection | DOAJ |
| description | <i>Strongyloides stercoralis</i> infection is generally asymptomatic or mildly symptomatic, but in the immunosuppressed host, it is associated with more severe and complicated forms with a worse prognosis. <i>S. stercoralis</i> seroprevalence was studied in 256 patients before receiving immunosuppressive treatment (before kidney transplantation or starting biological treatments). As a control group, serum bank data of 642 individuals representative of the population of the Canary Islands were retrospectively analyzed. To avoid false positives due to cross-reactivity with other similar helminth antigens present in the study area, IgG antibodies to <i>Toxocara</i> spp. and <i>Echinococcus</i> spp. were evaluated in cases positive for <i>Strongyloides</i>. The data show this is a prevalent infection: 1.1% of the Canarian population, 2.38% of Canarian individuals awaiting organ transplants and 4.8% of individuals about to start biological agents. On the other hand, strongyloidiasis can remain asymptomatic (as observed in our study population). There are no indirect data, such as country of origin or eosinophilia, to help raise suspicion of the disease. In summary, our study suggests that screening for <i>S. stercoralis</i> infection should be performed in patients who receive immunosuppressive treatment for solid organ transplantation or biological agents, in line with previous publications. |
| first_indexed | 2024-03-11T05:48:02Z |
| format | Article |
| id | doaj.art-59959afabecb464b8319612536bf081e |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-11T05:48:02Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-59959afabecb464b8319612536bf081e2023-11-17T14:15:34ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-03-018318110.3390/tropicalmed8030181Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain)Cristina Carranza-Rodríguez0Laura López-Delgado1Álvaro Granados-Magan2José-Luis Pérez-Arellano3Unidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainUnidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainDepartamento de Ciencias Médicas y Quirúrgicas, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, SpainUnidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain<i>Strongyloides stercoralis</i> infection is generally asymptomatic or mildly symptomatic, but in the immunosuppressed host, it is associated with more severe and complicated forms with a worse prognosis. <i>S. stercoralis</i> seroprevalence was studied in 256 patients before receiving immunosuppressive treatment (before kidney transplantation or starting biological treatments). As a control group, serum bank data of 642 individuals representative of the population of the Canary Islands were retrospectively analyzed. To avoid false positives due to cross-reactivity with other similar helminth antigens present in the study area, IgG antibodies to <i>Toxocara</i> spp. and <i>Echinococcus</i> spp. were evaluated in cases positive for <i>Strongyloides</i>. The data show this is a prevalent infection: 1.1% of the Canarian population, 2.38% of Canarian individuals awaiting organ transplants and 4.8% of individuals about to start biological agents. On the other hand, strongyloidiasis can remain asymptomatic (as observed in our study population). There are no indirect data, such as country of origin or eosinophilia, to help raise suspicion of the disease. In summary, our study suggests that screening for <i>S. stercoralis</i> infection should be performed in patients who receive immunosuppressive treatment for solid organ transplantation or biological agents, in line with previous publications.https://www.mdpi.com/2414-6366/8/3/181<i>Strongyloides stercoralis</i>kidney transplantationbiological therapies |
| spellingShingle | Cristina Carranza-Rodríguez Laura López-Delgado Álvaro Granados-Magan José-Luis Pérez-Arellano Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) Tropical Medicine and Infectious Disease <i>Strongyloides stercoralis</i> kidney transplantation biological therapies |
| title | Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) |
| title_full | Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) |
| title_fullStr | Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) |
| title_full_unstemmed | Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) |
| title_short | Seroprevalence of <em>Strongyloides stercoralis</em> in Patients about to Receive Immunosuppressive Treatment in Gran Canaria (Spain) |
| title_sort | seroprevalence of em strongyloides stercoralis em in patients about to receive immunosuppressive treatment in gran canaria spain |
| topic | <i>Strongyloides stercoralis</i> kidney transplantation biological therapies |
| url | https://www.mdpi.com/2414-6366/8/3/181 |
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