Evaluation of Some New Cytokines in Rheumatoid Arthritis
Background: Cytokines have an essential contribution to the inflammatory response and the development of chronic inflammation. Therefore, it has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). Interleukins are closely related to RA, and the exact role of some interleukins in the pa...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2022-10-01
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| Series: | مجلة كلية الطب |
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| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1963 |
| _version_ | 1797369797483167744 |
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| author | Zahra'a A. Ahmed |
| author_facet | Zahra'a A. Ahmed |
| author_sort | Zahra'a A. Ahmed |
| collection | DOAJ |
| description |
Background: Cytokines have an essential contribution to the inflammatory response and the development of chronic inflammation. Therefore, it has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). Interleukins are closely related to RA, and the exact role of some interleukins in the pathogenesis of RA is not yet known.
Objectives: To evaluate the levels of interleukins and their ratio, since the levels of interleukins 35 and 39 in RA patients have not yet been determined in Iraq.
Patients and methods: An ELISA (enzyme-linked immunosorbent assay) was used to measure the levels of interleukins in the blood of 56 patients with RA and 44 healthy volunteers who were enrolled in the study from November 2021 to March 2022.
Results: The serum levels of IL-39 in the RA patient groups were significantly higher than in the control groups (p = 0.043). In contrast, the level of IL-35 was slightly higher in RA patients but not by significantly different values (p = 0.055). The cytokine ratio, IL-39/IL-35, was the same for the groups, and there were no significant differences when comparing patients to controls (14.30 ± 1.47 vs. 13.18 ± 0.71). In addition, IL-39 concentration levels were significantly higher in RA patients under therapy than in RA patients with a first diagnosis and without therapy.
Conclusion: The study concluded the crucial role of pro-inflammatory and anti-inflammatory cytokines in the progression of RA.
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| first_indexed | 2024-03-08T17:53:11Z |
| format | Article |
| id | doaj.art-5996f550f6854a38887a6ce35bc18ceb |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:53:11Z |
| publishDate | 2022-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-5996f550f6854a38887a6ce35bc18ceb2024-01-02T06:46:22ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572022-10-0164310.32007/jfacmedbagdad.6431963Evaluation of Some New Cytokines in Rheumatoid ArthritisZahra'a A. Ahmed0College of Science for Women, University of Baghdad Background: Cytokines have an essential contribution to the inflammatory response and the development of chronic inflammation. Therefore, it has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). Interleukins are closely related to RA, and the exact role of some interleukins in the pathogenesis of RA is not yet known. Objectives: To evaluate the levels of interleukins and their ratio, since the levels of interleukins 35 and 39 in RA patients have not yet been determined in Iraq. Patients and methods: An ELISA (enzyme-linked immunosorbent assay) was used to measure the levels of interleukins in the blood of 56 patients with RA and 44 healthy volunteers who were enrolled in the study from November 2021 to March 2022. Results: The serum levels of IL-39 in the RA patient groups were significantly higher than in the control groups (p = 0.043). In contrast, the level of IL-35 was slightly higher in RA patients but not by significantly different values (p = 0.055). The cytokine ratio, IL-39/IL-35, was the same for the groups, and there were no significant differences when comparing patients to controls (14.30 ± 1.47 vs. 13.18 ± 0.71). In addition, IL-39 concentration levels were significantly higher in RA patients under therapy than in RA patients with a first diagnosis and without therapy. Conclusion: The study concluded the crucial role of pro-inflammatory and anti-inflammatory cytokines in the progression of RA. https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1963AutoimmunityIL-35IL-39Rheumatoid arthritis |
| spellingShingle | Zahra'a A. Ahmed Evaluation of Some New Cytokines in Rheumatoid Arthritis مجلة كلية الطب Autoimmunity IL-35 IL-39 Rheumatoid arthritis |
| title | Evaluation of Some New Cytokines in Rheumatoid Arthritis |
| title_full | Evaluation of Some New Cytokines in Rheumatoid Arthritis |
| title_fullStr | Evaluation of Some New Cytokines in Rheumatoid Arthritis |
| title_full_unstemmed | Evaluation of Some New Cytokines in Rheumatoid Arthritis |
| title_short | Evaluation of Some New Cytokines in Rheumatoid Arthritis |
| title_sort | evaluation of some new cytokines in rheumatoid arthritis |
| topic | Autoimmunity IL-35 IL-39 Rheumatoid arthritis |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1963 |
| work_keys_str_mv | AT zahraaaahmed evaluationofsomenewcytokinesinrheumatoidarthritis |