Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results
In this study, we compared the measurement of carotid stenosis by computed tomography angiography (CTA) based on the narrowest diameter versus cross sectional area (CSA) with the measurement by color Doppler ultrasonography (CDUS) as a reference standard, and analyzed how the application of diffe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2021-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/393695 |
| _version_ | 1797206793434169344 |
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| author | Kristina Samaržija Petar Milošević Zoran Jurjević Emilija Erdeljac |
| author_facet | Kristina Samaržija Petar Milošević Zoran Jurjević Emilija Erdeljac |
| author_sort | Kristina Samaržija |
| collection | DOAJ |
| description | In this study, we compared the measurement of carotid stenosis by computed tomography
angiography (CTA) based on the narrowest diameter versus cross sectional area (CSA) with
the measurement by color Doppler ultrasonography (CDUS) as a reference standard, and analyzed
how the application of different statistical methods affected the result. On 113 carotid arteries with
≥50% stenosis, we quantified the level of correlation among the three measurements, sensitivity, specificity,
and differences in the estimated stenosis level. Correlation between both CTA measurements
was good with Pearson’s ρ between 0.87 and 0.91 (p<0.001). Correlation between CDUS and CTA
measurements was only modest with Pearson’s ρ between 0.2 (p=0.075) and 0.4 (p=0,007) for CDUS
CTA (CSA), and between 0.23 (p=0.062) and 0.39 (p=0.008) for CDUS CTA (diameter). Differences
in stenosis between CTA (CSA) and CDUS were centered around 0%, and between CTA (diameter)
and CDUS around 20%. Sensitivity and specificity for CTA (CSA) method were 81% and
77%, and for CTA (diameter) 23% and 100%, respectively. A good correlation between CSA and diameter
measurement just means that these are two related features of stenosis, it does not mean good
agreement. CTA (CSA) method better detected surgical stenoses, whereas CTA (diameter) systematically
underestimated stenosis level. The study of differences between the measurements indicated
agreement better than the calculation of correlation coefficients. |
| first_indexed | 2024-04-24T09:12:40Z |
| format | Article |
| id | doaj.art-5997443d708b46e19f18f5af34703c60 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:12:40Z |
| publishDate | 2021-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-5997443d708b46e19f18f5af34703c602024-04-15T17:32:07ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512021-01-0160.3.45746510.20471/acc.2021.60.03.17Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the ResultsKristina Samaržija0Petar Milošević1Zoran Jurjević2Emilija Erdeljac3Department of Radiology, Karlovac General Hospital, Karlovac, CroatiaDepartment of Vascular Surgery, Karlovac General Hospital, Karlovac, CroatiaDepartment of Radiology, Karlovac General Hospital, Karlovac, CroatiaDepartment of Neurology, Karlovac General Hospital, Karlovac, CroatiaIn this study, we compared the measurement of carotid stenosis by computed tomography angiography (CTA) based on the narrowest diameter versus cross sectional area (CSA) with the measurement by color Doppler ultrasonography (CDUS) as a reference standard, and analyzed how the application of different statistical methods affected the result. On 113 carotid arteries with ≥50% stenosis, we quantified the level of correlation among the three measurements, sensitivity, specificity, and differences in the estimated stenosis level. Correlation between both CTA measurements was good with Pearson’s ρ between 0.87 and 0.91 (p<0.001). Correlation between CDUS and CTA measurements was only modest with Pearson’s ρ between 0.2 (p=0.075) and 0.4 (p=0,007) for CDUS CTA (CSA), and between 0.23 (p=0.062) and 0.39 (p=0.008) for CDUS CTA (diameter). Differences in stenosis between CTA (CSA) and CDUS were centered around 0%, and between CTA (diameter) and CDUS around 20%. Sensitivity and specificity for CTA (CSA) method were 81% and 77%, and for CTA (diameter) 23% and 100%, respectively. A good correlation between CSA and diameter measurement just means that these are two related features of stenosis, it does not mean good agreement. CTA (CSA) method better detected surgical stenoses, whereas CTA (diameter) systematically underestimated stenosis level. The study of differences between the measurements indicated agreement better than the calculation of correlation coefficients.https://hrcak.srce.hr/file/393695Carotid stenosisCT angiographyColor Doppler ultrasonographyStatistical data analysis |
| spellingShingle | Kristina Samaržija Petar Milošević Zoran Jurjević Emilija Erdeljac Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results Acta Clinica Croatica Carotid stenosis CT angiography Color Doppler ultrasonography Statistical data analysis |
| title | Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results |
| title_full | Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results |
| title_fullStr | Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results |
| title_full_unstemmed | Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results |
| title_short | Comparison of Carotid Stenosis Grading by CT Angiography and Doppler Ultrasonography: How the Statistical Methods Applied Influence the Results |
| title_sort | comparison of carotid stenosis grading by ct angiography and doppler ultrasonography how the statistical methods applied influence the results |
| topic | Carotid stenosis CT angiography Color Doppler ultrasonography Statistical data analysis |
| url | https://hrcak.srce.hr/file/393695 |
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