The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice
Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Correspondent author: Seyed Mohammad Ali Shariatzadeh, s-shariatzadeh@araku.ac.ir Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause t...
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| Format: | Article |
| Language: | English |
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Kharazmi University
2022-09-01
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| Series: | یافتههای نوین در علوم زیستی |
| Subjects: | |
| Online Access: | http://nbr.khu.ac.ir/article-1-3511-en.html |
| _version_ | 1828411191906533376 |
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| author | Seyed Mohammad Ali Shariatzadeh Zahra Alizadeh |
| author_facet | Seyed Mohammad Ali Shariatzadeh Zahra Alizadeh |
| author_sort | Seyed Mohammad Ali Shariatzadeh |
| collection | DOAJ |
| description | Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh
Department of Biology, Faculty of Sciences, Arak University, Arak, Iran
Correspondent author: Seyed Mohammad Ali Shariatzadeh, s-shariatzadeh@araku.ac.ir
Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause toxicity in the ovaries. The aim of this study is to see if Spirulina platensis (SP) can protect mouse from Ag NPs-exposed toxicity in its ovary. Twenty-four female Naval Medical Research Institute (NMRI) mice were divided into four groups (n = 6 per group): control; Ag NPs (500 mg/kg daily); SP (300 mg/kg daily) and Ag NPs + SP (With the same defined doses). 30 days after oral gavage treatment, biochemical parameters were measured and ovary compartments were estimated stereologically. The Ferric Reducing Antioxidant Power (FRAP) values, hormonal concentrations, corpus luteum volume, and the number of healthy follicles were all significantly lower (p<0.05) in the Ag NPs group compared with the control group. in the SP group, malondialdehyde concentration and atretic follicles were significantly lower (p<0.05) compared with the control group. There was no significant difference in the mean total volume of ovary, cortex, medulla, oocyte and its nucleus, and the thickness of the zona pellucida in any group. Although, SP in the Ag NPs + SP group cannot compensate the above parameters to the control level, it considerably improves ovarian damage caused by Ag NPs through reducing oxidative stress.
Key words. follicles, hormones, oxidative stress, stereology, zona pellucida |
| first_indexed | 2024-12-10T12:26:39Z |
| format | Article |
| id | doaj.art-59979e1b472b462ba777c96b475e2063 |
| institution | Directory Open Access Journal |
| issn | 2423-6330 2476-7115 |
| language | English |
| last_indexed | 2024-12-10T12:26:39Z |
| publishDate | 2022-09-01 |
| publisher | Kharazmi University |
| record_format | Article |
| series | یافتههای نوین در علوم زیستی |
| spelling | doaj.art-59979e1b472b462ba777c96b475e20632022-12-22T01:48:57ZengKharazmi Universityیافتههای نوین در علوم زیستی2423-63302476-71152022-09-01928194The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed miceSeyed Mohammad Ali Shariatzadeh0Zahra Alizadeh1 Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Correspondent author: Seyed Mohammad Ali Shariatzadeh, s-shariatzadeh@araku.ac.ir Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause toxicity in the ovaries. The aim of this study is to see if Spirulina platensis (SP) can protect mouse from Ag NPs-exposed toxicity in its ovary. Twenty-four female Naval Medical Research Institute (NMRI) mice were divided into four groups (n = 6 per group): control; Ag NPs (500 mg/kg daily); SP (300 mg/kg daily) and Ag NPs + SP (With the same defined doses). 30 days after oral gavage treatment, biochemical parameters were measured and ovary compartments were estimated stereologically. The Ferric Reducing Antioxidant Power (FRAP) values, hormonal concentrations, corpus luteum volume, and the number of healthy follicles were all significantly lower (p<0.05) in the Ag NPs group compared with the control group. in the SP group, malondialdehyde concentration and atretic follicles were significantly lower (p<0.05) compared with the control group. There was no significant difference in the mean total volume of ovary, cortex, medulla, oocyte and its nucleus, and the thickness of the zona pellucida in any group. Although, SP in the Ag NPs + SP group cannot compensate the above parameters to the control level, it considerably improves ovarian damage caused by Ag NPs through reducing oxidative stress. Key words. follicles, hormones, oxidative stress, stereology, zona pellucidahttp://nbr.khu.ac.ir/article-1-3511-en.htmlstereologyfollicleshormonesoxidative stresszona pellucida |
| spellingShingle | Seyed Mohammad Ali Shariatzadeh Zahra Alizadeh The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice یافتههای نوین در علوم زیستی stereology follicles hormones oxidative stress zona pellucida |
| title | The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice |
| title_full | The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice |
| title_fullStr | The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice |
| title_full_unstemmed | The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice |
| title_short | The protective effect of Spirulina platensis on the ovary of silver nanoparticle-exposed mice |
| title_sort | protective effect of spirulina platensis on the ovary of silver nanoparticle exposed mice |
| topic | stereology follicles hormones oxidative stress zona pellucida |
| url | http://nbr.khu.ac.ir/article-1-3511-en.html |
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