Spontaneous Hepatocellular Adenoma in Paediatric Age Group – Case Report
Hepatocellular adenoma (Hca) is a rare, benign, liver cell tumour. Hca is most frequently seen in women with a history of oral contraceptive use. Hca is also reported in children with glycogen storage disorders, galactosaemia, Hurler’s syndrome, severe immune deficiency states, diabetes mellitus,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3706/89-%206773_E(C)_F(P)_PFA(NC)_PF1(PP).pdf |
| Summary: | Hepatocellular adenoma (Hca) is a rare, benign, liver cell tumour. Hca is most frequently seen in women with a history of oral contraceptive
use. Hca is also reported in children with glycogen storage disorders, galactosaemia, Hurler’s syndrome, severe immune deficiency states,
diabetes mellitus, sex hormone disturbances, Fanconis anaemia, in those who are on androgen therapy and also in seizure disorder
patients who are on carbamazepine therapy. Usually, Hca arises typically in a clinical setting of hormonal or metabolic abnormalities which
stimulate hepatocyte proliferation. Though it is rare, a few cases of spontaneous Hca have been reported in children and also in adults,
which were not associated with any of the known risk factors which are associated with Hca. Hca has to be differentiated from focal nodular
hyperplasia, hepatocellular carcinoma and hepatoblastoma. The histological features and the assessment of cell proliferation by using
immuno histochemistry, help in confirming the diagnosis of Hca. In a few cases of Hca, malignant transformations have been reported.
Hence, a careful search for malignant transformations is necessary. In this report, we have documented two cases of spontaneous Hca
which occurred in two normal children. |
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| ISSN: | 2249-782X 0973-709X |