Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity
The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective. Computational modeling is challenged by the fact that many details remain hitherto unknown and conventional approaches to describe synaptic functio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-12-01
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| Series: | Frontiers in Computational Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00098/full |
| _version_ | 1818175031717396480 |
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| author | Maurizio eDe Pitta' Vladislav eVolman Vladislav eVolman Vladislav eVolman Hugues eBerry Vladimir eParpura Vladimir eParpura Andrea eVolterra Eshel eBen-Jacob Eshel eBen-Jacob Eshel eBen-Jacob |
| author_facet | Maurizio eDe Pitta' Vladislav eVolman Vladislav eVolman Vladislav eVolman Hugues eBerry Vladimir eParpura Vladimir eParpura Andrea eVolterra Eshel eBen-Jacob Eshel eBen-Jacob Eshel eBen-Jacob |
| author_sort | Maurizio eDe Pitta' |
| collection | DOAJ |
| description | The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective. Computational modeling is challenged by the fact that many details remain hitherto unknown and conventional approaches to describe synaptic function are unsuitable to explain experimental observations when astrocytic signaling is taken into account. Supported by experimental evidence is the possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission. Here we consider the plausibility of this scenario from a theoretical perspective, focusing on the modulation of synaptic release probability by the astrocyte and its implications on synaptic plasticity. The analysis of the signaling pathways underlying such modulation refines our notion of the tripartite synapse and has profound implications on our understanding of brain function. |
| first_indexed | 2024-12-11T19:53:50Z |
| format | Article |
| id | doaj.art-599994d1adc64a8eb374aa3a7d708618 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-12-11T19:53:50Z |
| publishDate | 2012-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-599994d1adc64a8eb374aa3a7d7086182022-12-22T00:52:42ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882012-12-01610.3389/fncom.2012.0009827925Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticityMaurizio eDe Pitta'0Vladislav eVolman1Vladislav eVolman2Vladislav eVolman3Hugues eBerry4Vladimir eParpura5Vladimir eParpura6Andrea eVolterra7Eshel eBen-Jacob8Eshel eBen-Jacob9Eshel eBen-Jacob10Tel Aviv UniversityUniversity of California at San DiegoThe Salk Institute for Biological StudiesL-3 Applied TechnologiesINRIA Rhône-AlpesUniversity of AlabamaUniversity or RijekaUniversity of LausanneTel Aviv UniversityRice UniversityAssaf Harofeh Medical CenterThe complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective. Computational modeling is challenged by the fact that many details remain hitherto unknown and conventional approaches to describe synaptic function are unsuitable to explain experimental observations when astrocytic signaling is taken into account. Supported by experimental evidence is the possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission. Here we consider the plausibility of this scenario from a theoretical perspective, focusing on the modulation of synaptic release probability by the astrocyte and its implications on synaptic plasticity. The analysis of the signaling pathways underlying such modulation refines our notion of the tripartite synapse and has profound implications on our understanding of brain function.http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00098/fullAstrocytesCalcium SignalingSynaptic Transmissionsynaptic plasticitymodellinggliotransmission |
| spellingShingle | Maurizio eDe Pitta' Vladislav eVolman Vladislav eVolman Vladislav eVolman Hugues eBerry Vladimir eParpura Vladimir eParpura Andrea eVolterra Eshel eBen-Jacob Eshel eBen-Jacob Eshel eBen-Jacob Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity Frontiers in Computational Neuroscience Astrocytes Calcium Signaling Synaptic Transmission synaptic plasticity modelling gliotransmission |
| title | Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| title_full | Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| title_fullStr | Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| title_full_unstemmed | Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| title_short | Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| title_sort | computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity |
| topic | Astrocytes Calcium Signaling Synaptic Transmission synaptic plasticity modelling gliotransmission |
| url | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00098/full |
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