Complement Receptor 3 Has Negative Impact on Tumor Surveillance through Suppression of Natural Killer Cell Function

Complement Receptor 3 Has Negative Impact on Tumor Surveillance through Suppression of Natural Killer Cell Function

Complement receptor 3 (CR3) is expressed abundantly on natural killer (NK) cells; however, whether it plays roles in NK cell-dependent tumor surveillance is largely unknown. Here, we show that CR3 is an important negative regulator of NK cell function, which has negative impact on tumor surveillance...

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Bibliographic Details
Main Authors: Cheng-Fei Liu, Xiao-Yun Min, Naiyin Wang, Jia-Xing Wang, Ning Ma, Xia Dong, Bing Zhang, Weiju Wu, Zong-Fang Li, Wuding Zhou, Ke Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
complement receptor 3
Melanoma
iC3b
natural killer cell function
tumor surveillance
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01602/full

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