Anti-atherogenic effects of fibrates in type 2 diabetes
<p>Abstract</p> <p>Type 2 diabetes is an increasing cause of premature coronary heart disease. Several trials with lipid-modifying therapy have included sufficient numbers of diabetics to indicate that treatment of diabetic dyslipidaemia with either fibrates or statins reduces the...
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Format: | Article |
Language: | English |
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BMC
2001-09-01
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Series: | Current Controlled Trials in Cardiovascular Medicine |
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Online Access: | http://cvm.controlled-trials.com/content/2/5/218 |
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author | Barter Philip |
author_facet | Barter Philip |
author_sort | Barter Philip |
collection | DOAJ |
description | <p>Abstract</p> <p>Type 2 diabetes is an increasing cause of premature coronary heart disease. Several trials with lipid-modifying therapy have included sufficient numbers of diabetics to indicate that treatment of diabetic dyslipidaemia with either fibrates or statins reduces the risk of future coronary events in such patients. However, until recently no reported study had been designed specifically to investigate the effects of intervening in patients with type 2 diabetes. The Diabetes Atherosclerosis Intervention Study (DAIS) is an angiographic study in which 418 diabetic subjects were randomized to micronised fenofibrate or placebo groups. After 3 years of treatment, the fenofibrate group had a significantly reduced rate of progression of coronary atherosclerosis. This study, when considered with the results of other studies that have included diabetics, has important implications for the treatment of diabetic dyslipidaemia. The evidence that is currently available supports a place for both fibrates and statins, either as monotherapy or in combination, in the treatment of diabetic dyslipidaemia.</p> |
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format | Article |
id | doaj.art-599f073b81da4955853f6e12a43b349c |
institution | Directory Open Access Journal |
issn | 1468-6708 |
language | English |
last_indexed | 2024-12-12T05:32:39Z |
publishDate | 2001-09-01 |
publisher | BMC |
record_format | Article |
series | Current Controlled Trials in Cardiovascular Medicine |
spelling | doaj.art-599f073b81da4955853f6e12a43b349c2022-12-22T00:36:16ZengBMCCurrent Controlled Trials in Cardiovascular Medicine1468-67082001-09-012521822010.1186/cvm-2-5-218Anti-atherogenic effects of fibrates in type 2 diabetesBarter Philip<p>Abstract</p> <p>Type 2 diabetes is an increasing cause of premature coronary heart disease. Several trials with lipid-modifying therapy have included sufficient numbers of diabetics to indicate that treatment of diabetic dyslipidaemia with either fibrates or statins reduces the risk of future coronary events in such patients. However, until recently no reported study had been designed specifically to investigate the effects of intervening in patients with type 2 diabetes. The Diabetes Atherosclerosis Intervention Study (DAIS) is an angiographic study in which 418 diabetic subjects were randomized to micronised fenofibrate or placebo groups. After 3 years of treatment, the fenofibrate group had a significantly reduced rate of progression of coronary atherosclerosis. This study, when considered with the results of other studies that have included diabetics, has important implications for the treatment of diabetic dyslipidaemia. The evidence that is currently available supports a place for both fibrates and statins, either as monotherapy or in combination, in the treatment of diabetic dyslipidaemia.</p>http://cvm.controlled-trials.com/content/2/5/218atherosclerosisdiabetesfenofibratefibratestatin |
spellingShingle | Barter Philip Anti-atherogenic effects of fibrates in type 2 diabetes Current Controlled Trials in Cardiovascular Medicine atherosclerosis diabetes fenofibrate fibrate statin |
title | Anti-atherogenic effects of fibrates in type 2 diabetes |
title_full | Anti-atherogenic effects of fibrates in type 2 diabetes |
title_fullStr | Anti-atherogenic effects of fibrates in type 2 diabetes |
title_full_unstemmed | Anti-atherogenic effects of fibrates in type 2 diabetes |
title_short | Anti-atherogenic effects of fibrates in type 2 diabetes |
title_sort | anti atherogenic effects of fibrates in type 2 diabetes |
topic | atherosclerosis diabetes fenofibrate fibrate statin |
url | http://cvm.controlled-trials.com/content/2/5/218 |
work_keys_str_mv | AT barterphilip antiatherogeniceffectsoffibratesintype2diabetes |