Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence.
Recent work has revealed that Clostridioides difficile, a major cause of nosocomial diarrheal disease, exhibits phenotypic heterogeneity within a clonal population as a result of phase variation. Many C. difficile strains representing multiple ribotypes develop two colony morphotypes, termed rough a...
Main Authors: | Elizabeth M Garrett, Ognjen Sekulovic, Daniela Wetzel, Joshua B Jones, Adrianne N Edwards, Germán Vargas-Cuebas, Shonna M McBride, Rita Tamayo |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-10-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3000379 |
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